E2F8

E2F transcription factor 8

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

E2F8 (3)

Publications

No (3)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human E2F8 Protein (Recombinant GST) (Full Length) - LS-G35264

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

73.15 kDa

Price:

10 µg/$479; 25 µg/$670

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E2F8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G109829

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

94 kDa

Price:

100 µg/$710

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Human E2F8 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87443

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

94 kDa

Price:

20 µg/$215

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