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E2F8

E2F transcription factor 8

Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1: component of a feedback loop in S phase by repressing the expression of E2F1, thereby preventing p53/TP53-dependent apoptosis. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins (E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene.

Gene Name: E2F transcription factor 8
Synonyms: E2F8, E2F family member 8, E2F-8, E2F transcription factor 8, Transcription factor E2F8
Target Sequences: NM_024680 NP_078956.2 A0AVK6

Publications (1)

1
Small Nuclear Ribonucleoprotein Polypeptide N Accelerates Malignant Progression and Poor Prognosis in Colorectal Cancer Transcriptionally Regulated by E2F8. Meiling Ji, Li Ren, Yang Lv, Xinyuan Lao, Qingyang Feng, Wentao Tang, Aobo Zhuang, Tianyu Liu, Peng Zheng, Jianmin Xu. Frontiers in oncology. 2020 November;10:561287. [Full Text Article] [PubMed:33224876] [PMC:PMC7669248] Related Antibodies: LS-C804191.

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Antibodies (26)
Primary (26)
E2F8 (26)
Human (26)
Mouse (2)
Rat (4)
Bat (4)
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Dog (4)
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Guinea pig (3)
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IHC (1)
WB (25)
ELISA (9)
IP (2)
Peptide-ELISA (3)
rabbit (18)
mouse (7)
goat (1)
IgG (8)
IgG1,k (7)
monoclonal mc (7)
polyclonal pc (19)
3E9-2F5 (1)
AP Conjugated (1)
APC Conjugated (1)
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FITC Conjugated (4)
HRP Conjugated (4)
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Unconjugated (11)
C-Terminus (8)
N-Terminus (4)
aa402-416 (1)
aa817-867 (1)
aa835-865 (1)
No (25)
Yes (1)
E2F8 Antibody - 1:100 staining human spleen tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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E2F8 Rabbit anti-Human Polyclonal Antibody
Human
IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
E2F8 Antibody - E2F8 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
E2F8 Antibody - E2F8 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
E2F8 Antibody - E2F8 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
E2F8 Antibody - E2F8 antibody Western blot of COLO205 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Dog, Guinea pig, Rat, Hamster, Pig, Horse, Bat, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
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E2F8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$331
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E2F8 Mouse anti-Human Monoclonal (3E9-2F5) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$655
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E2F8 Mouse anti-Human Monoclonal (HRP) Antibody
Human
ELISA, WB
HRP Conjugated
100 µl/$917
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E2F8 Mouse anti-Human Monoclonal (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
100 µl/$917
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E2F8 Mouse anti-Human Monoclonal (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
100 µl/$917
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E2F8 Mouse anti-Human Monoclonal (PE) Antibody
Human
ELISA, WB
PE Conjugated
100 µl/$917
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E2F8 Mouse anti-Human Monoclonal (AP) Antibody
Human
ELISA, WB
AP Conjugated
100 µl/$917
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E2F8 Mouse anti-Human Monoclonal (APC) Antibody
Human
ELISA, WB
APC Conjugated
100 µl/$917
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E2F8 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$357
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E2F8 Rabbit anti-Human Polyclonal (aa817-867) Antibody
Mouse, Human
IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
E2F8 Antibody - All lanes: Anti-E2F8 Antibody (C-Term) at 1:2000 dilution. Lane 1: A431 whole cell lysate. Lane 2: HepG2 whole cell lysate Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1:10000 dilution. Predicted band size: 94 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
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E2F8 Rabbit anti-Human Polyclonal (aa835-865) Antibody
Human
Peptide-ELISA, WB
Unconjugated
200 µl/$393
E2F8 Antibody - Western blot analysis of extracts of SW480 cell line, using E2F8 antibody.
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E2F8 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$377; 200 µl/$503
E2F8 Antibody - Western blot of Human PANC1. E2F8 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
E2F8 Antibody - Western blot of Human PANC1. E2F8 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
HRP Conjugated
100 µl/$469
E2F8 Antibody - Western blot of Human PANC1. E2F8 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
E2F8 Antibody - Western blot of Human PANC1. E2F8 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Horse, Orangutan, Gibbon, Human, Monkey, Chimpanzee
WB
FITC Conjugated
100 µl/$469
E2F8 Antibody - Western blot of E2F8 Antibody with human RPMI-8226 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
E2F8 Antibody - Western blot of E2F8 Antibody with human RPMI-8226 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
E2F8 Antibody - Western blot of E2F8 Antibody with human RPMI-8226 Whole Cell lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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E2F8 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
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E2F8 Goat anti-Human Polyclonal (aa402-416) Antibody
Rabbit, Dog, Bovine, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA
Unconjugated
100 µg/$493
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