E2F1

E2F transcription factor 1

E2F-1 (also known as transcription factor E2F-1, Retinoblastoma binding protein 3, RBBP-3, PRB-binding protein E2F-1, PBR3, Retinoblastoma-associated protein 1 and RBAP-1) is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein as well as E2F2 and E2F3 have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.

☰ Filters

Products

Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

E2F1 (4)

Publications

No (4)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Select

Human E2F1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G67141

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

20 µg/$1,107

Select

E2F1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G116095

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

100 µg/$494

Select

Human E2F1 Protein (Recombinant GST, N-terminus) (aa348-437) - LS-G58393

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human E2F1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G79217

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

46.7 kDa

Price:

20 µg/$150

Viewing 1-4 of 4 product results

(0) Selected Add Selected To Cart Compare Selected Email Selected Clear Selected Top Of Search

---

Filtered By:

Products: Proteins

Clear Filters

If you do not find the reagent or information you require, please contact Customer.Support@LSBio.com to inquire about additional products in development.