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DYRK3
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
DYRK3 belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified.
| Gene Name: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 |
| Family/Subfamily: | Protein Kinase , MNB/DYRK |
| Synonyms: | DYRK3, DYRK5, RED, REDK, Protein kinase Dyrk3, Regulatory erythroid kinase, HYAK3-2 |
| Target Sequences: | NM_003582 NP_003573.2 O43781 |
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