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DYRK / DYRK1A
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK / DYRK1A is a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms.
| Gene Name: | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A |
| Family/Subfamily: | Protein Kinase , MNB/DYRK |
| Synonyms: | DYRK1A, DYRK1, DYRK, HMNB, HP86, MNB, MNB/DYRK protein kinase, MRD7, MNBH, Serine/threonine kinase MNB, Yak1-related kinase |
| Target Sequences: | NM_001396 NP_001387.2 Q13627 |
Publications (1)
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