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DYNLL1 / PIN

dynein, light chain, LC8-type 1

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.Binds and inhibits the catalytic activity of neuronal nitric oxide synthase.Promotes transactivation functions of ESR1 and plays a role in the nuclear localization of ESR1.Regulates apoptotic activities of BCL2L11 by sequestering it to microtubules. Upon apoptotic stimuli the BCL2L11-DYNLL1 complex dissociates from cytoplasmic dynein and translocates to mitochondria and sequesters BCL2 thus neutralizing its antiapoptotic activity.

Gene Name: dynein, light chain, LC8-type 1
Synonyms: DYNLL1, 8 kDa dynein light chain, DLC8, Dynein light chain LC8-type 1, DNCL1, DNCLC1, PIN, LC8a, Hdlc1, LC8
Target Sequences: NM_003746 NP_003737.1 P63167

☰ Filters
Products
Proteins (17)
Over-Expression Lysate (8)
Recombinant (9)
DYNLL1 / PIN (17)
No (17)
6His, N-terminus (2)
GST (2)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (11)
Human (13)
293T Cells (4)
E. coli (4)
HEK 293 Cells (7)
Wheat Germ Extract (2)
Purified (2)
Low endotoxin level (2)
DYNLL1 / PIN Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$469; 25 µg/$630
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E. coli
GST
37.8 kD
1 mg/$1,207; 100 µg/$408; 20 µg/$311
DYNLL1 / PIN Protein - Purified recombinant protein DYNLL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$1,005
DYNLL1 / PIN Protein - Purified recombinant protein DYNLL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$1,005
DYNLL1 / PIN Protein - Purified recombinant protein DYNLL1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$1,005
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
100 µg/$412
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
100 µg/$458
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$130
Select
293T Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$110
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$130
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
10.2 kDa
20 µg/$130
DYNLL1 / PIN Protein - 12.5% SDS-PAGE of human DYNLL1 stained with Coomassie Blue
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Wheat Germ Extract
GST
36.8 kDa
10 µg/$469; 25 µg/$630
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
100 µg/$458
DYNLL1 / PIN Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
10.2 kDa
100 µg/$458
DYNLL1 / PIN Protein
Select
E. coli
His
100 µg/$351; 500 µg/$694; 20 µg/$249
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.5 kDa
10 µg/$307; 50 µg/$514
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E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
12.5kD
10 µg/$306; 50 µg/$509; 500 µg/$1,439; 1 mg/$2,055
Viewing 1-17 of 17 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).