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DXO / DOM3Z
decapping exoribonuclease
Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping, pyrophosphohydrolase and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates.
| Gene Name: | decapping exoribonuclease |
| Synonyms: | DXO, Dom-3 homolog Z, DOM3L, Dom-3 homolog Z (C. elegans), DOM3Z, DOM-3 (C. elegans) homolog Z, NG6, Protein Dom3Z, decapping and exoribonuclease protein |
| Target Sequences: | NM_005510 NP_005501.2 O77932 |
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