DUT / DUTPase

deoxyuridine triphosphatase

DUT / DUTPase is an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

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Products

Proteins (14)

Type

Over-Expression Lysate (4)

Recombinant (10)

Target

DUT / DUTPase (14)

Publications

No (14)

Tag

6His, N-terminus (2)

GST (1)

GST, N-terminus (2)

His (1)

Myc-DDK (Flag) (6)

Species

Human (12)

Source

293T Cells (2)

E. coli (5)

HEK 293 Cells (4)

Wheat Germ Extract (3)

Purification

Purified (4)

Low Endotoxin Level

Low endotoxin level (4)

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Human DUT / DUTPase Protein (Recombinant 6His, N-terminus) (Met1-Asn164) - LS-G140143

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.0 kDa

Price:

10 µg/$344; 50 µg/$584

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Human DUT / DUTPase Protein (Recombinant) (Met1-Asn164) - LS-G139447

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.7 kDa

Price:

10 µg/$368; 50 µg/$504

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DUT / DUTPase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G121040

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.56 kDa

Price:

100 µg/$494

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Human DUT / DUTPase Protein (Recombinant GST) (Full Length) - LS-G28271

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

53 kDa

Price:

2 µg/$439

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Human DUT / DUTPase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75476

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

26.56 kDa

Price:

20 µg/$150

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Human DUT / DUTPase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75478

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

20 µg/$150

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Human DUT / DUTPase Protein (Recombinant GST, N-terminus) (aa41-122) - LS-G58388

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DUT / DUTPase Protein (Recombinant GST, N-terminus) (aa68-164) - LS-G58387

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DUT / DUTPase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65388

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

20 µg/$1,107

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Human DUT / DUTPase Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65389

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

15.2 kDa

Price:

20 µg/$1,107

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DUT / DUTPase Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99599

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.6 kDa

Price:

100 µg/$494

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Human DUT / DUTPase Protein (Recombinant His) - LS-G949

Source:

E. coli

Tag:

His

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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Human DUT / DUTPase Protein (Recombinant) (Met1-Asn164) - LS-G39649

Source:

E. coli

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

17.7kD

Price:

10 µg/$281; 50 µg/$420; 500 µg/$1,585; 1 mg/$2,157

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Human DUT / DUTPase Protein (Recombinant 6His, N-terminus) (Met1-Asn164) - LS-G51862

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20kD

Price:

10 µg/$321; 50 µg/$534; 500 µg/$1,585; 1 mg/$2,353

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