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DUT / DUTPase

deoxyuridine triphosphatase

DUT / DUTPase is an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.

Gene Name: deoxyuridine triphosphatase
Synonyms: DUT, Deoxyuridine triphosphatase, DUTP pyrophosphatase, DUT-N, DUTP nucleotidohydrolase, DUTPase
Target Sequences: NM_001948 NP_001939.1 P33316

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Products
Antibodies (44)
Primary (44)
DUT / DUTPase (44)
Human (44)
Mouse (10)
Rat (12)
Bat (3)
Dog (3)
Gibbon (3)
Guinea pig (3)
Horse (3)
Monkey (2)
Sheep (1)
Yeast (3)
Zebrafish (3)
IHC (30)
IHC-P (13)
WB (39)
ELISA (14)
IF (2)
IP (4)
Peptide-ELISA (1)
rabbit (41)
mouse (1)
goat (1)
chicken (1)
Product Group
IHCPlus (3)
IgG (30)
IgG1,k (1)
IgY (1)
monoclonal mc (1)
polyclonal pc (43)
1C9 (1)
APC Conjugated (2)
Azide-free (1)
Biotin Conjugated (4)
FITC Conjugated (4)
HRP Conjugated (4)
Magnetic beads Conjugated (1)
PE Conjugated (2)
Sepharose Conjugated (1)
Unconjugated (26)
aa170-198 (7)
C-Terminus (4)
aa35-84 (4)
Internal (3)
aa136-150 (2)
aa25-44 (2)
aa1-52 (1)
No (44)
DUT / DUTPase Antibody - Anti-DUT antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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DUT / DUTPase Mouse anti-Human Monoclonal (1C9) Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$460
DUT / DUTPase Antibody - DUT antibody DUT(dUTP pyrophosphatase) Antibody was used in IHC to stain formalin-fixed, paraffin-embedded human heart.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUT / DUTPase Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$397
DUT / DUTPase Antibody - DUT / DUTPase antibody. IHC(P): Human Intestinal Cancer Tissue.
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa136-150) Antibody
Mouse, Sheep, Human, Monkey
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
DUT / DUTPase Antibody - Western blot detection of DUT-N in HeLa cell lysate using antibody at a dilution of 1:1000.
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa25-44) Antibody
Human
WB
Unconjugated
200 µl/$386
DUT / DUTPase Antibody - Anti-DUT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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DUT / DUTPase Chicken anti-Human Polyclonal (aa1-52) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µg/$485
DUT / DUTPase Antibody - Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DUT / DUTPase Goat anti-Human Polyclonal Antibody
Human
IHC-P, Peptide-ELISA, WB
Unconjugated
50 µg/$460
DUT / DUTPase Antibody - Immunohistochemistry of paraffin-embedded Rat spleen using DUT Polyclonal Antibody at dilution of 1:100 (40x lens).
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, IP, WB
Unconjugated
100 µg/$564
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$466
DUT / DUTPase Antibody - Immunohistochemistry of paraffin-embedded Human brain using DUT Polyclonal Antibody at dilution of 1:30.
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa136-150) Antibody
Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µg/$614
DUT / DUTPase Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUT / DUTPase Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
DUT / DUTPase Antibody - DUT Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human colon tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa170-198) Antibody
Human
IHC, IHC-P, WB
Unconjugated
400 µl/$393
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
50 µl/$356; 100 µl/$461
DUT / DUTPase Antibody - Immunohistochemistry of paraffin-embedded Human tonsil tissue  using DUT Polyclonal Antibody at dilution of 1:70(×200)
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DUT / DUTPase Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer tissue  using DUT Polyclonal Antibody at dilution of 1:60(×200)
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DUT / DUTPase Rabbit anti-Human Polyclonal Antibody
Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
DUT / DUTPase Antibody - Immunohistochemistry with Jurkat cell lysate tissue.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DUT / DUTPase Rabbit anti-Human Polyclonal (aa35-84) Antibody
Human
IHC, WB
Unconjugated
100 µl/$424
Viewing 1-25 of 44 product results


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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).