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Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. DUSP7 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK (see MIM 601795), JNK (see MIM 601158), and p38 (see MIM 600289) with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25 (see MIM 116947)-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses (summary by Patterson et al., 2009 [PubMed 19228121]).
Gene Name: | dual specificity phosphatase 7 |
Family/Subfamily: | Protein Phosphatase , Dual specificity MKP |
Synonyms: | DUSP7, Dual specificity phosphatase 7, Map kinase phosphatase x, MKPX, VHX, PYST2, Dual-specificity phosphatase-7, MKP-X |
Target Sequences: | AF508727 AAM77606.1 Q16829 |
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