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DUSP6 / MKP3
dual specificity phosphatase 6
MKP3 / DUSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene.
| Gene Name: | dual specificity phosphatase 6 |
| Family/Subfamily: | Protein Phosphatase , Dual specificity MKP |
| Synonyms: | DUSP6, Dual specificity phosphatase 6, MAP kinase phosphatase 3, MKP3, PYST1, RVH6, Mapk phosphatase 3, MKP-3, Phosphatase VH6 |
| Target Sequences: | NM_001946 NP_001937.2 Q16828 |
Publications (2)
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