DUSP4 / MKP2

dual specificity phosphatase 4

TYP / DUSP4 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

DUSP4 / MKP2 (7)

Publications

No (7)

Tag

GST (1)

Myc-DDK (Flag) (6)

Species

Human (5)

Source

293T Cells (2)

HEK 293 Cells (4)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human DUSP4 / MKP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65477

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$1,107

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Human DUSP4 / MKP2 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65481

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.8 kDa

Price:

20 µg/$1,107

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Human DUSP4 / MKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75639

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.8 kDa

Price:

20 µg/$150

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Human DUSP4 / MKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75641

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

20 µg/$150

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Human DUSP4 / MKP2 Protein (Recombinant GST) (Full Length) - LS-G28267

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

69.08 kDa

Price:

10 µg/$479; 25 µg/$670

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DUSP4 / MKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G99427

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

42.8 kDa

Price:

100 µg/$494

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DUSP4 / MKP2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G102180

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

32.8 kDa

Price:

100 µg/$494

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