DUSP3 / VHR

dual specificity phosphatase 3

DUSP3 / VHR is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

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Products

Proteins (12)

Type

Over-Expression Lysate (2)

Recombinant (10)

Target

DUSP3 / VHR (12)

Publications

No (12)

Tag

6His, N-terminus (1)

GST (2)

GST, N-terminus (1)

His (2)

His,N-terminus (1)

His-GST (1)

Myc-DDK (Flag) (3)

Species

Human (11)

Source

293T Cells (1)

Baculovirus (2)

E. coli (4)

HEK 293 Cells (2)

Wheat Germ Extract (3)

Purification

Purified (3)

Low Endotoxin Level

Low endotoxin level (4)

Biologically Active

Biologically active (1)

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Human DUSP3 / VHR Protein (Recombinant) (Met1-Pro185) - LS-G98687

Source:

Baculovirus

Tag:

None

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

20.6 kDa

Price:

100 µg/$721

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Human DUSP3 / VHR Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G65476

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$1,107

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Human DUSP3 / VHR Protein (Recombinant GST, N-terminus) (aa76-185) - LS-G58382

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DUSP3 / VHR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75638

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

20 µg/$150

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Human DUSP3 / VHR Protein (Recombinant His) (aa2-185) - LS-G15712

Source:

E. coli

Tag:

His

Molecular Weight:

21.9 kDa

Price:

10 µg/$255; 50 µg/$323; 100 µg/$450; 200 µg/$562; 1 mg/$1,480; 500 µg/$1,096; 5 mg/$2,395; 2 mg/$1,646

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Human DUSP3 / VHR Protein (Recombinant GST) (Full Length) - LS-G28265

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

46.09 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DUSP3 / VHR Protein (Recombinant GST) (Full Length) - LS-G28266

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

41.58 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DUSP3 / VHR Protein (Recombinant 6His, N-terminus) (Ser2-Pro185) - LS-G39147

Source:

E. coli

Tag:

6His, N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.6kD

Price:

10 µg/$281; 50 µg/$395; 500 µg/$1,585; 1 mg/$2,157

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DUSP3 / VHR Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100204

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

20.3 kDa

Price:

100 µg/$494

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Human DUSP3 / VHR Protein (Recombinant His,N-terminus) (Ser2-Pro185) - LS-G139418

Source:

E. coli

Tag:

His,N-terminus

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

22.6 kDa

Price:

10 µg/$368; 50 µg/$479

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Human DUSP3 / VHR Protein (Recombinant His-GST) (Met1-Pro185) - LS-G98017

Source:

Baculovirus

Tag:

His-GST

Endotoxin Level:

Less than 1.0 EU/µg protein (determined by LAL method).

Molecular Weight:

48.3 kDa

Price:

100 µg/$721

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Human DUSP3 / VHR Protein (Recombinant His) - LS-G1456

Source:

E. coli

Tag:

His

Biological Activity:

Biologically active

Price:

100 µg/$361; 500 µg/$739; 20 µg/$261

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