DUSP3 / VHR

dual specificity phosphatase 3

DUSP3 / VHR is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

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ELISA Kits (3)

Type

Custom (1)

Sandwich (2)

Target

DUSP3 / VHR (3)

Reactivity

Human (2)

Mouse (1)

Format

96-Well Microplate (1)

96-Well Strip Plate (2)

Publications

No (3)

Sample Type

Plasma (2)

Serum (2)

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Human DUSP3 / VHR (Custom ELISA) ELISA Kit - LS-F50765

Type:

Custom

Format:

96-Well Microplate

Reactivity:

Human

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$923

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Human DUSP3 / VHR (Sandwich ELISA) ELISA Kit - LS-F49468

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Mouse DUSP3 / VHR (Sandwich ELISA) ELISA Kit - LS-F66729

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.156 - 10 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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