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DUSP26 / MKP8
dual specificity phosphatase 26 (putative)
Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).
| Gene Name: | dual specificity phosphatase 26 (putative) |
| Family/Subfamily: | Protein Phosphatase , Dual Specificity MKP |
| Synonyms: | DUSP26, DSP-4, NATA1, SKRP3, MAP kinase phosphatase 8, MKP-8, DUSP24, LDP-4, LDP4, MKP8 |
| Target Sequences: | NM_024025 NP_076930.1 Q9BV47 |
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