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DUSP22 / JSP 1

dual specificity phosphatase 22

MKPX, also known as JSP-1 for Jnk Stimulatory Phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated in a number of important physiological processes, including embryonic morphogenesis, cell survival and apoptosis. At least two mRNA transcripts have been reported. Jnk signaling has been linked to human disease conditions, such as tumor development, cardiac hypertrophy, ischemia/reperfusion injury, diabetes, hyperglycemia-induced apoptosis, and several neurodegenerative disorders.

Gene Name: dual specificity phosphatase 22
Family/Subfamily: Protein Phosphatase , LMW-DSP
Synonyms: DUSP22, JSP 1, JKAP, JNK-stimulating phosphatase 1, LMW-DSP2, Map kinase phosphatase x, MKPX, VHX, JNK-stimulatory phosphatase-1, JSP-1, JSP1, LMWDSP2, MKP-X
Target Sequences: NM_020185 NP_064570.1 Q9NRW4

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Products
Proteins (7)
Over-Expression Lysate (2)
Recombinant (5)
DUSP22 / JSP 1 (7)
No (7)
GST (1)
GST, N-terminus (2)
His (1)
His, N-Terminal (1)
Myc-DDK (Flag) (2)
Human (6)
293T Cells (1)
E. coli (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (3)
DUSP22 / JSP 1 Protein - 12.5% SDS-PAGE of human DUSP22 stained with Coomassie Blue
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Wheat Germ Extract
GST
47.3 kDa
2 µg/$439
DUSP22 / JSP 1 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
DUSP22 / JSP 1 Protein
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E. coli
His, N-Terminal
20.9 kDa
50 µg/$419
DUSP22 / JSP 1 Protein
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E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276
DUSP22 / JSP 1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
GST, N-terminus
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DUSP22 / JSP 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
20.7 kDa
20 µg/$150
DUSP22 / JSP 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
20.7 kDa
100 µg/$494
Viewing 1-7 of 7 product results


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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).