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DUSP16 / MKP7
dual specificity phosphatase 16
MKP7 is a dual specificity MAP kinase phosphatase which has been shown to bind and inactivate kinases p38 (isoforms alpha and beta) and JNK, but not ERK. A mutant form MKP7 has been shown to function as a dominant negative, particularly against the dephosphorylation of JNK in vitro, suggesting that MKP7 works as a JNK-specific phosphatase in vivo. Detailed transcriptional mapping of 12p12 chromosomal region has identified MKP7 as a possible tumor suppressor gene.
| Gene Name: | dual specificity phosphatase 16 |
| Family/Subfamily: | Protein Phosphatase , Dual specificity MKP |
| Synonyms: | DUSP16, MAPK phosphatase-7, MKP7, MAP kinase phosphatase 7, MKP-7, KIAA1700 |
| Target Sequences: | AB052156 BAB40814.1 Q9BY84 |
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