DUSP12

dual specificity phosphatase 12

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized predominantly in the nucleus, and is novel in that it contains, and is regulated by a zinc finger domain.

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Proteins (5)

Type

Over-Expression Lysate (2)

Recombinant (3)

Target

DUSP12 (5)

Publications

No (5)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (4)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DUSP12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G87002

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

20 µg/$150

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DUSP12 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114772

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

100 µg/$494

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Human DUSP12 Protein (Recombinant GST) (Full Length) - LS-G32591

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.03 kDa

Price:

10 µg/$479; 25 µg/$670

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Human DUSP12 Protein (Recombinant GST, N-terminus) (aa231-340) - LS-G61807

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DUSP12 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G70404

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.5 kDa

Price:

20 µg/$1,107

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