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DUSP10 / MKP5

dual specificity phosphatase 10

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.

Gene Name: dual specificity phosphatase 10
Synonyms: DUSP10, MAP kinase phosphatase 5, MKP-5, MKP5
Target Sequences: NM_007207 NP_009138.1 Q9Y6W6

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Proteins (6)
Over-Expression Lysate (4)
Recombinant (2)
DUSP10 / MKP5 (6)
No (6)
GST (1)
His (1)
Myc-DDK (Flag) (4)
Human (4)
293T Cells (2)
E. coli (1)
HEK 293 Cells (2)
Wheat Germ Extract (1)
Purified (2)
DUSP10 / MKP5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
52.5 kDa
20 µg/$150
DUSP10 / MKP5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
15.9 kDa
20 µg/$150
DUSP10 / MKP5 Protein - 12.5% SDS-PAGE of human DUSP10 stained with Coomassie Blue
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Wheat Germ Extract
GST
41.14 kDa
10 µg/$479; 25 µg/$670
DUSP10 / MKP5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
15.9 kDa
100 µg/$494
DUSP10 / MKP5 Protein
Select
E. coli
His
100 µg/$411; 500 µg/$985; 20 µg/$276; 10 µg/$246; 50 µg/$323; 250 µg/$585
DUSP10 / MKP5 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
52.5 kDa
100 µg/$494
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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).