DTX1 / Deltex

deltex 1, E3 ubiquitin ligase

Functions as a ubiquitin ligase protein in vivo, mediating ubiquitination and promoting degradation of MEKK1, suggesting that it may regulate the Notch pathway via some ubiquitin ligase activity (By similarity). Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations. Mainly acts as a positive regulator of Notch, but it also acts as a negative regulator, depending on the developmental and cell context. Mediates the antineural activity of Notch, possibly by inhibiting the transcriptional activation mediated by MATCH1. Involved in neurogenesis, lymphogenesis and myogenesis, and may also be involved in MZB (Marginal zone B) cell differentiation. Promotes B-cell development at the expense of T-cell development, suggesting that it can antagonize NOTCH1.

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Products

Proteins (3)

Type

Recombinant (3)

Target

DTX1 / Deltex (3)

Publications

No (3)

Tag

GST (1)

GST, N-terminus (1)

His-T7 (1)

Species

Human (3)

Source

E. coli (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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Human DTX1 / Deltex Protein (Recombinant GST, N-terminus) (aa381-470) - LS-G58379

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DTX1 / Deltex Protein (Recombinant His-T7) (aa290-535) - LS-G26105

Source:

E. coli

Tag:

His-T7

Molecular Weight:

30.3 kDa

Price:

10 µg/$278; 50 µg/$422; 100 µg/$672; 200 µg/$842; 1 mg/$1,934; 500 µg/$1,480; 5 mg/$2,941; 2 mg/$2,119

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Human DTX1 / Deltex Protein (Recombinant GST) (Full Length) - LS-G28262

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

93.8 kDa

Price:

2 µg/$439

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