DTNBP1 / Dysbindin

dystrobrevin binding protein 1

Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Associates with the BLOC-2 complex to facilitate the transport of TYRP1 independent of AP-3 function. Plays a role in synaptic vesicle trafficking and in neurotransmitter release. Plays a role in the regulation of cell surface exposure of DRD2. May play a role in actin cytoskeleton reorganization and neurite outgrowth. May modulate MAPK8 phosphorylation. Appears to promote neuronal transmission and viability through regulating the expression of SNAP25 and SYN1, modulating PI3-kinase-Akt signaling and influencing glutamatergic release. Regulates the expression of SYN1 through binding to its promoter. Modulates prefrontal cortical activity via the dopamine/D2 pathway.

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Products

ELISA Kits (6)

Type

Custom (4)

Sandwich (2)

Target

DTNBP1 / Dysbindin (6)

Reactivity

Human (2)

Mouse (1)

Rat (1)

Chicken (1)

Format

96-Well Strip Plate (6)

Publications

No (6)

Sample Type

Plasma (2)

Serum (2)

Tissue Homogenates (1)

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Human DTNBP1 / Dysbindin (Sandwich ELISA) ELISA Kit - LS-F33753

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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Mouse DTNBP1 / Dysbindin (Custom ELISA) ELISA Kit - LS-F17538

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Mouse

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Rat DTNBP1 / Dysbindin (Custom ELISA) ELISA Kit - LS-F17537

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Rat

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

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Chicken DTNBP1 / Dysbindin (Custom ELISA) ELISA Kit - LS-F17539

Type:

Custom

Format:

96-Well Strip Plate

Reactivity:

Chicken

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$929

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Bovine DTNBP1 / Dysbindin (Custom ELISA) ELISA Kit - LS-F17540

Type:

Custom

Format:

96-Well Strip Plate

Detection:

Colorimetric - 450nm (TMB)

Price:

1 Plate/$783

Select

Human DTNBP1 / Dysbindin (Sandwich ELISA) ELISA Kit - LS-F13153

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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