DTL / CDT2

denticleless E3 ubiquitin protein ligase homolog (Drosophila)

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1) and SETD8. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. SETD8 degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling, cell cycle progression, DNA repair and cell migration. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

DTL / CDT2 (3)

Publications

No (3)

Tag

GST, N-terminus + His, C-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (1)

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Human DTL / CDT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90396

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.3 kDa

Price:

20 µg/$150

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Human DTL / CDT2 Protein (Recombinant GST, N-terminus + His, C-terminus) - LS-G144700

Source:

E. coli

Tag:

GST, N-terminus + His, C-terminus

Molecular Weight:

105.3 kDa

Price:

50 µg/$419

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DTL / CDT2 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G101435

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

79.3 kDa

Price:

100 µg/$494

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