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DSC1 / Desmocollin 1

desmocollin 1

DSC1 / Desmocollin 1 is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms.

Gene Name: desmocollin 1
Family/Subfamily: Cadherin , not assigned-Cadherin
Synonyms: DSC1, Desmocollin-1, Desmocollin 1, Desmosomal glycoprotein 2/3, DG2/DG3, Cadherin family member 1, CDHF1
Target Sequences: NM_024421 NP_077739.1 Q08554

Publications (1)

1
BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality. Ikawa-Yoshida A, Matsumoto T, Okano S, Aoyagi Y, Matsubara Y, Furuyama T, Nakatsu Y, Tsuzuki T, Onimaru M, Ohkusa T, Nomura M, Maehara Y. Scientific reports. 2016 6:32399. (WB; Human) [Full Text Article] [PubMed:27561386] [PMC:PMC4999951] Related Antibodies: LS-C167539.

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Proteins (3)
Over-Expression Lysate (1)
Recombinant (2)
DSC1 / Desmocollin 1 (3)
No (3)
His (2)
Myc-DDK (Flag) (1)
Human (1)
Mouse (1)
E. coli (2)
HEK 293 Cells (1)
DSC1 / Desmocollin 1 Protein - Recombinant Desmocollin 1 By SDS-PAGE
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E. coli
His
24.3 kDa
10 µg/$261; 50 µg/$337; 100 µg/$507; 200 µg/$632; 1 mg/$1,609; 500 µg/$1,201; 5 mg/$2,546; 2 mg/$1,781
DSC1 / Desmocollin 1 Protein - Recombinant Desmocollin 1 By SDS-PAGE
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E. coli
His
24.8 kDa
10 µg/$271; 50 µg/$382; 100 µg/$610; 200 µg/$762; 1 mg/$1,817; 500 µg/$1,378; 5 mg/$2,775; 2 mg/$1,998
DSC1 / Desmocollin 1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
96.9 kDa
100 µg/$710
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).