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DRD3 / Dopamine Receptor D3

dopamine receptor D3

DRD3 / Dopamine Receptor D3 is the D3 subtype of the five (D1-D5) dopamine receptors. The activity of the D3 subtype receptor is mediated by G proteins which inhibit adenylyl cyclase. This receptor is localized to the limbic areas of the brain, which are associated with cognitive, emotional, and endocrine functions. Genetic variation in this gene may be associated with susceptibility to hereditary essential tremor 1. Alternative splicing of this gene results in transcript variants encoding different isoforms, although some variants may be subject to nonsense-mediated decay (NMD).

Gene Name: dopamine receptor D3
Family/Subfamily: GPCR , Dopamine
Synonyms: DRD3, D3DR, D3nf, Essential tremor 1, ETM1, FET1, D(3) dopamine receptor
Target Sequences: NM_000796 NP_000787.2 P35462

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).