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Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. Accurate initiation of transcription from eukaryotic protein-encoding genes requires the assembly of a large multiprotein complex consisting of RNA polymerase II and general transcription factors such as TFIIA, TFIIB, and TFIID. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The protein encoded by this gene is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. The interaction between this corepressor and DR1 is required for corepressor function and appears to stabilize the TBP-DR1-DNA complex.
Gene Name: | DR1-associated protein 1 (negative cofactor 2 alpha) |
Synonyms: | DRAP1, Nc2 alpha subunit, NC2-alpha, Negative cofactor 2 alpha, Dr1-associated corepressor, Dr1-associated protein 1, Negative co-factor 2-alpha |
Target Sequences: | NM_006442 NP_006433.2 Q14919 |
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