DPPA3 / STELLA

developmental pluripotency associated 3

Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC: specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent/pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

DPPA3 / STELLA (4)

Publications

No (4)

Tag

His (1)

His-T7 (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

E. coli (2)

HEK 293 Cells (1)

Purification

Purified (1)

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Human DPPA3 / STELLA Protein (Recombinant His-T7) (aa1-159) - LS-G24855

Source:

E. coli

Tag:

His-T7

Molecular Weight:

21.6 kDa

Price:

10 µg/$267; 50 µg/$352; 100 µg/$562; 200 µg/$702; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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Human DPPA3 / STELLA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93066

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.7 kDa

Price:

20 µg/$150

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DPPA3 / STELLA Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G103376

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

17.7 kDa

Price:

100 µg/$494

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Human DPPA3 / STELLA Protein (Recombinant His) - LS-G1952

Source:

E. coli

Tag:

His

Price:

50 µg/$411; 250 µg/$985; 10 µg/$276

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