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Shirley, MA 01464
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20700 44th Avenue W
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DPM3
dolichyl-phosphate mannosyltransferase polypeptide 3
Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. The protein encoded by this gene is a subunit of dolichyl-phosphate mannosyltransferase and acts as a stabilizer subunit of the dolichyl-phosphate mannosyltransferase complex.
| Gene Name: | dolichyl-phosphate mannosyltransferase polypeptide 3 |
| Synonyms: | DPM3, CDG1O, DPM synthase complex subunit 3, MPD synthase subunit 3 |
| Target Sequences: | NM_018973 NP_061846.2 Q9P2X0 |
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