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DPH2 is one of two human genes similar to the yeast gene dph2. The yeast gene was identified by its ability to complement a diphthamide mutant strain, and thus probably functions in diphthamide biosynthesis. Diphthamide is a post-translationally modified histidine residue present in elongation factor 2 (EF2) that is the target of diphtheria toxin ADP-ribosylation. Two transcript variants encoding different isoforms have been found for this gene.
Gene Name: | DPH2 homolog (S. cerevisiae) |
Synonyms: | DPH2, DPH2 homolog, DPH2L2, DPH2 homolog (S. cerevisiae), DPH2-like 2, HsDph2, DPH2-like 2 (S. cerevisiae) |
Target Sequences: | NM_001384 NP_001375.2 Q9BQC3 |
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