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DOCK3 is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement.
Gene Name: | Dedicator Of Cytokinesis 3 |
Synonyms: | DOCK3, Dedicator of cyto-kinesis 3, MOCA, Modifier of cell adhesion, PBP, KIAA0299, Presenilin-binding protein, Dedicator of cytokinesis 3 |
Target Sequences: | AB002297 BAA20759.1 Q8IZD9 |
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