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DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Gene Name:	DNA (cytosine-5-)-methyltransferase 3 beta
Family/Subfamily:	C5-methyltransferase
Synonyms:	DNMT3B, DNA MTase HsaIIIB, ICF, ICF1, M.HsaIIIB, DNA methyltransferase HsaIIIB
Target Sequences:	NM_006892 NP_008823.1 Q9UBC3

Publications (12)

DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. Nature. 2002 416:552-6. (WB; Human) [PubMed:11932749]

Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human) [PubMed:12406579]

DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human) [PubMed:12496760]

Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells. Qiu YY, Mirkin BL, Dwivedi RS. Cancer detection and prevention. 2002 26:444-53. (ICC, WB; Mouse) [PubMed:12507229]

Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. Xiong Y, Dowdy SC, Podratz KC, Jin F, Attewell JR, Eberhardt NL, Jiang SW. Cancer research. 2005 65:2684-9. (WB; Human) [PubMed:15805266]

DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, Smiraglia DJ, James SR, Yu J, Moser MT, Foster BA, Karpf AR. Cancer research. 2006 66:11659-67. (WB; Mouse) [PubMed:17178860]

Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Molecular cancer research : MCR. 2008 6:1365-74. (WB; Mouse) [PubMed:18667590] [PMC:PMC2835734]

Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. Kinney SM, Chin HG, Vaisvila R, Bitinaite J, Zheng Y, Estve PO, Feng S, Stroud H, Jacobsen SE, Pradhan S. The Journal of biological chemistry. 2011 286:24685-93. (WB; Mouse) [PubMed:21610077] [PMC:PMC3137044]

Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Carcinogenesis. 2011 32:1450-8. [PubMed:21771726]

DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. Molecular cancer therapeutics. 2012 11:370-82. [PubMed:22203734]

DNA methyltransferase 3b regulates articular cartilage homeostasis by altering metabolism. Shen J, Wang C, Li D, Xu T, Myers J, Ashton JM, Wang T, Zuscik MJ, McAlinden A, O'Keefe RJ. JCI insight. 2017 2: (WB; Human) [Full Text Article] [PubMed:28614801] [PMC:PMC5470890] Related Antibodies: LS-C111224.

Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease. Zoltan Szabolcsi, Amanda Demeter, Peter Kiraly, Andrea Balogh, Melissa L Wilson, Jennifer R King, Szabolcs Hetey, Zsolt Gelencser, Koji Matsuo, Beata Hargitai, Paulette Mhawech-Fauceglia, Petronella Hupuczi, Andras Szilagyi, Zoltan Papp, Lynda D Roman, Victoria K Cortessis, Nandor Gabor Than. Biomedicines. 2021 December;9: [Full Text Article] [PubMed:34944751] [PMC:PMC8698431] Related Antibodies: LS-C352124.

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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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