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Unfortunately, the antibody (ID:34185) is no longer available.

Below is a list of antibodies to the same protein target. You may also try your search again using the search box at the top of the page. Please contact us if you have any questions.



DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

Gene Name: DNA (cytosine-5-)-methyltransferase 3 beta
Family/Subfamily: C5-methyltransferase
Synonyms: DNMT3B, DNA MTase HsaIIIB, ICF, ICF1, M.HsaIIIB, DNA methyltransferase HsaIIIB
Target Sequences: NM_006892 NP_008823.1 Q9UBC3

Publications (11)

1
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells. Rhee I, Bachman KE, Park BH, Jair KW, Yen RW, Schuebel KE, Cui H, Feinberg AP, Lengauer C, Kinzler KW, Baylin SB, Vogelstein B. Nature. 2002 416:552-6. (WB; Human) [PubMed:11932749]
2
Identification and characterization of alternatively spliced variants of DNA methyltransferase 3a in mammalian cells. Weisenberger DJ, Velicescu M, Preciado-Lopez MA, Gonzales FA, Tsai YC, Liang G, Jones PA. Gene. 2002 298:91-9. (Mouse, Human) [PubMed:12406579]
3
DNMT1 is required to maintain CpG methylation and aberrant gene silencing in human cancer cells. Robert MF, Morin S, Beaulieu N, Gauthier F, Chute IC, Barsalou A, MacLeod AR. Nature genetics. 2003 33:61-5. (WB; Human) [PubMed:12496760]
4
Differential expression of DNA-methyltransferases in drug resistant murine neuroblastoma cells. Qiu YY, Mirkin BL, Dwivedi RS. Cancer detection and prevention. 2002 26:444-53. (ICC, WB; Mouse) [PubMed:12507229]
5
Histone deacetylase inhibitors decrease DNA methyltransferase-3B messenger RNA stability and down-regulate de novo DNA methyltransferase activity in human endometrial cells. Xiong Y, Dowdy SC, Podratz KC, Jin F, Attewell JR, Eberhardt NL, Jiang SW. Cancer research. 2005 65:2684-9. (WB; Human) [PubMed:15805266]
6
DNA methylation pathway alterations in an autochthonous murine model of prostate cancer. Morey SR, Smiraglia DJ, James SR, Yu J, Moser MT, Foster BA, Karpf AR. Cancer research. 2006 66:11659-67. (WB; Mouse) [PubMed:17178860]
7
Stage-specific alterations of DNA methyltransferase expression, DNA hypermethylation, and DNA hypomethylation during prostate cancer progression in the transgenic adenocarcinoma of mouse prostate model. Morey Kinney SR, Smiraglia DJ, James SR, Moser MT, Foster BA, Karpf AR. Molecular cancer research : MCR. 2008 6:1365-74. (WB; Mouse) [PubMed:18667590] [PMC:PMC2835734]
8
SIRT1 activation by resveratrol ameliorates cisplatin-induced renal injury through deacetylation of p53. Kim DH, Jung YJ, Lee JE, Lee AS, Kang KP, Lee S, Park SK, Han MK, Lee SY, Ramkumar KM, Sung MJ, Kim W. American journal of physiology. Renal physiology. 2011 301:F427-35. [PubMed:21593185]
9
Tissue-specific distribution and dynamic changes of 5-hydroxymethylcytosine in mammalian genomes. Kinney SM, Chin HG, Vaisvila R, Bitinaite J, Zheng Y, Estve PO, Feng S, Stroud H, Jacobsen SE, Pradhan S. The Journal of biological chemistry. 2011 286:24685-93. (WB; Mouse) [PubMed:21610077] [PMC:PMC3137044]
10
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL. Kaminskyy VO, Surova OV, Vaculova A, Zhivotovsky B. Carcinogenesis. 2011 32:1450-8. [PubMed:21771726]
11
DNA methyltransferase inhibitor, zebularine, delays tumor growth and induces apoptosis in a genetically engineered mouse model of breast cancer. Chen M, Shabashvili D, Nawab A, Yang SX, Dyer LM, Brown KD, Hollingshead M, Hunter KW, Kaye FJ, Hochwald SN, Marquez VE, Steeg P, Zajac-Kaye M. Molecular cancer therapeutics. 2012 11:370-82. [PubMed:22203734]
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Filtered By: None
Target
dnmt3b (37)
Reactivity
Human (32)
Mouse (20)
Rat (9)
Bat (4)
Bovine (4)
Chicken (4)
Chimpanzee (3)
Dog (4)
Gibbon (3)
Guinea pig (4)
Horse (4)
Monkey (5)
Pig (5)
Rabbit (4)
Zebrafish (4)
Application
IHC (12)
IHC-P (7)
WB (36)
Flo (3)
ChrIP (2)
DB (2)
ELISA (13)
ICC (9)
IF (8)
IP (4)
Host
rabbit (28)
mouse (8)
chicken (1)
Isotype
IgG (17)
IgG1 (1)
IgG1,k (3)
IgG2b (3)
Clonality
monoclonal mc (8)
polyclonal pc (29)
Clone
2280C3a (2)
52A1018 (2)
ABM1C25 (1)
Format
AP Conjugated (1)
APC Conjugated (1)
Azide-free (2)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (26)
Epitope
aa395-425 (7)
aa647-696 (4)
aa581-859 (3)
C-Terminus (1)
His7 (1)
N-Terminus (1)
aa1-50 (1)
aa1-80 (1)
aa356-390 (1)
aa389-417 (1)
aa403-417 (1)
aa7-56 (1)
Publications
No (37)
Showing 1-25 out of 37 results
Anti-DNMT3B Antibody (aa1-50) IHC-plus™ LS-B5671

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IF IHC-P WB
Unconjugated
Anti-DNMT3B Antibody (clone 52A1018) LS-C523

Mouse Monoclonal [clone 52A1018] (IgG) to Mouse DNMT3B
Mouse, Human
ChrIP ICC IHC-P IP WB
Unconjugated
Anti-DNMT3B Antibody LS-C96074

Chicken Polyclonal to Human DNMT3B
Mouse, Human
IHC WB
Unconjugated
Anti-DNMT3B Antibody (clone 2280C3a) LS-C342441

Mouse Monoclonal [clone 2280C3a] (IgG2b) to Human DNMT3B
Mouse, Rat, Human
DB Flo ICC IF WB
Unconjugated
Anti-DNMT3B Antibody (aa647-696) LS-C111224

Rabbit Polyclonal to Human DNMT3B
Chicken, Zebrafish, Pig, Horse, Bat, Rat, Bovine, Rabbit, Mouse, Dog, Guinea pig, Human, Monkey
WB
Unconjugated
Anti-DNMT3B Antibody (clone 52A1018, Azide-free) LS-C368273

Mouse Monoclonal [clone 52A1018] (IgG1,k) to Mouse DNMT3B
Mouse, Human
ChrIP ICC IF IHC-P IP WB
Unconjugated, Azide-free
Anti-DNMT3B Antibody (N-Terminus) LS-C352124

Rabbit Polyclonal to Human DNMT3B
Human, Monkey
ICC IF IHC-P WB
Unconjugated
Anti-DNMT3B Antibody (aa1-80) LS-C383179

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IF IHC WB
Unconjugated
Anti-DNMT3B Antibody LS-C64792

Mouse Monoclonal (IgG1,k) to Human DNMT3B
Mouse, Human
ICC IF IP WB
Unconjugated
Anti-DNMT3B Antibody (clone 2280C3a) LS-C184392

Mouse Monoclonal [clone 2280C3a] (IgG2b) to Human DNMT3B
Mouse, Rat, Human
DB Flo ICC WB
Unconjugated
Anti-DNMT3B Antibody (clone ABM1C25) LS-C358128

Mouse Monoclonal [clone ABM1C25] (IgG1,k) to Human DNMT3B
Human
Flo IHC WB
Unconjugated
Anti-DNMT3B Antibody LS-C417310

Rabbit Polyclonal to Human DNMT3B
Human
IF IHC WB
Unconjugated
Anti-DNMT3B Antibody (aa7-56) IHC-plus™ LS-B14664

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC-P WB
Unconjugated
Anti-DNMT3B Antibody LS-C6418

Mouse Monoclonal (IgG1) to Mouse DNMT3B
Mouse
ICC IP WB
Unconjugated
Anti-DNMT3B Antibody (aa395-425) LS-C320919

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
Unconjugated
Anti-DNMT3B Antibody (aa395-425, Biotin) LS-C234721

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
Biotin Conjugated
Anti-DNMT3B Antibody (aa395-425, FITC) LS-C234722

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
FITC Conjugated
Anti-DNMT3B Antibody (aa395-425, AP) LS-C234719

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
AP Conjugated
Anti-DNMT3B Antibody (aa395-425, APC) LS-C234720

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
APC Conjugated
Anti-DNMT3B Antibody (aa395-425, PE) LS-C234727

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
PE Conjugated
Anti-DNMT3B Antibody (aa395-425, Azide-free, HRP) LS-C249860

Rabbit Polyclonal (IgG) to Human DNMT3B
Human
ELISA IHC WB
HRP Conjugated, Azide-free
Anti-DNMT3B Antibody LS-C332279

Rabbit Polyclonal (IgG) to Human DNMT3B
Mouse, Human
IHC WB
Unconjugated
Anti-DNMT3B Antibody (His7) LS-C177069

Rabbit Polyclonal to Human DNMT3B
Human
IF IHC-P WB
Unconjugated
Anti-DNMT3B Antibody (aa356-390) LS-C392650

Rabbit Polyclonal to Mouse DNMT3B
Mouse
ELISA WB
Unconjugated
Anti-DNMT3B Antibody (aa581-859, Biotin) LS-C424697

Rabbit Polyclonal (IgG) to Mouse DNMT3B
Mouse
ICC WB
Biotin Conjugated

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If you do not find the reagent or information you require, please contact customer.support@lsbio.com to inquire about additional products in development.

PLEASE NOTE

For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).


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