DNMT3B

DNA (cytosine-5-)-methyltransferase 3 beta

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing (By similarity). In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Function as transcriptional corepressor by associating with ZHX1.

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Products

Proteins (7)

Type

Over-Expression Lysate (4)

Recombinant (3)

Target

DNMT3B (7)

Publications

No (7)

Tag

6His, N-terminus (1)

GST, N-terminus (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Mouse (1)

Source

293T Cells (2)

E. coli (1)

HEK 293 Cells (3)

Wheat Germ Extract (1)

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Mouse DNMT3B Protein (Recombinant 6His, N-terminus) (aa581-859) - LS-G25972

Source:

E. coli

Tag:

6His, N-terminus

Molecular Weight:

35.5 kDa

Price:

10 µg/$279; 50 µg/$432; 100 µg/$690; 200 µg/$862; 1 mg/$1,962; 500 µg/$1,505; 5 mg/$3,011; 2 mg/$2,148

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Human DNMT3B Protein (Recombinant GST, N-terminus) (aa221-320) - LS-G58354

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

2 µg/$439

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Human DNMT3B Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71359

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.6 kDa

Price:

20 µg/$1,107

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Human DNMT3B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89575

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.8 kDa

Price:

20 µg/$215

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Human DNMT3B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G89577

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

20 µg/$215

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DNMT3B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104971

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

86 kDa

Price:

100 µg/$710

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DNMT3B Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G114997

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.8 kDa

Price:

100 µg/$710

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