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DNM1L / DRP1

dynamin 1-like

Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division, ensures the survival of at least some types of postmitotic neurons, including Purkinje cells, by suppressing oxidative damage. Required for normal brain development, including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Also required for mitochondrial fission during mitosis. Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.Isoform 1 and isoform 4 inhibit peroxisomal division when overexpressed.

Gene Name: dynamin 1-like
Synonyms: DNM1L, DYMPLE, Dynamin 1-like, Dynamin-like protein, Dynamin-like protein 4, Dynamin-like protein IV, DLP1, Dnm1p/Vps1p-like protein, DVLP, Dynamin-related protein 1, DYNIV-11, DRP1, Dynamin-1-like protein, VPS1, EMPF, HDYNIV
Target Sequences: NM_012062 NP_036192.2 O00429

Publications (9)

1
Sensory neuropathy attributable to loss of Bcl-w. Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:1624-34. (WB; Mouse) [PubMed:21289171] [PMC:PMC3074348]
2
Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. Manczak M, Calkins MJ, Reddy PH. Human molecular genetics. 2011 20:2495-509. [PubMed:21459773] [PMC:PMC3109997]
3
High-mobility group box 1 is essential for mitochondrial quality control. Tang D, Kang R, Livesey KM, Kroemer G, Billiar TR, Van Houten B, Zeh HJ, Lotze MT. Cell metabolism. 2011 13:701-11. (ICC, WB; Mouse) [PubMed:21641551] [PMC:PMC3293110]
4
Role of Drp1, a key mitochondrial fission protein, in neuropathic pain. Ferrari LF, Chum A, Bogen O, Reichling DB, Levine JD. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011 31:11404-10. [PubMed:21813700] [PMC:PMC3157245]
5
Impaired mitochondrial biogenesis, defective axonal transport of mitochondria, abnormal mitochondrial dynamics and synaptic degeneration in a mouse model of Alzheimer's disease. Calkins MJ, Manczak M, Mao P, Shirendeb U, Reddy PH. Human molecular genetics. 2011 20:4515-29. [PubMed:21873260] [PMC:PMC3209824]
6
Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer. Rehman J, Zhang HJ, Toth PT, Zhang Y, Marsboom G, Hong Z, Salgia R, Husain AN, Wietholt C, Archer SL. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2012 26:2175-86. (IHC, WB; Human) [PubMed:22321727] [PMC:PMC3336787]
7
Dynamin-related protein 1 heterozygote knockout mice do not have synaptic and mitochondrial deficiencies. Manczak M, Sesaki H, Kageyama Y, Reddy PH. Biochimica et biophysica acta. 2012 1822:862-74. (WB; Mouse) [PubMed:22387883] [PMC:PMC3338881]
8
Dynamin-related protein 1-mediated mitochondrial mitotic fission permits hyperproliferation of vascular smooth muscle cells and offers a novel therapeutic target in pulmonary hypertension. Marsboom G, Toth PT, Ryan JJ, Hong Z, Wu X, Fang YH, Thenappan T, Piao L, Zhang HJ, Pogoriler J, Chen Y, Morrow E, Weir EK, Rehman J, Archer SL. Circulation research. 2012 110:1484-97. (ICC, IHC, WB; Human) [PubMed:22511751] [PMC:PMC3539779]
9
High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. Luzzo KM, Wang Q, Purcell SH, Chi M, Jimenez PT, Grindler N, Schedl T, Moley KH. PloS one. 2012 7:e49217. (ICC, IHC; Mouse) [PubMed:23152876] [PMC:PMC3495769]
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Antibodies (46)
Primary (46)
DNM1L / DRP1 (46)
Human (46)
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No (46)
DNM1L / DRP1 Antibody - Anti-DNM1L / DRP1 antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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DNM1L / DRP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, ICC, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI4F6) Antibody
Mouse, Dog, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Carcinoma of Human lung tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4F6) Antibody
Mouse, Dog, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI2E7) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI2E7) Antibody
Mouse, Rat, Human, Monkey
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI3F4) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3F4) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - Immunoperoxidase of monoclonal antibody to DNM1L on formalin-fixed paraffin-embedded human leiomyosarcoma tissue. [antibody concentration 1 ug/ml].
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DNM1L / DRP1 Mouse anti-Human Monoclonal (3B5) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
100 µg/$423
DNM1L / DRP1 Antibody - Immunofluorescence of HeLa cells using DNM1L mouse monoclonal antibody (green). Blue: DRAQ5 fluorescent DNA dye.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (aa69-213) (4A4C7) Antibody
Human
ELISA, Flo, IF, WB
Unconjugated
100 µl/$459
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI3F3) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI3F3) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI1C1) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI1C1) Antibody
Human
IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody
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DNM1L / DRP1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$286; 100 µl/$321
DNM1L / DRP1 Antibody - Immunohistochemistry: DRP1 Antibody (4E11B11) - IHC analysis of paraffin-embedded human cerebellum tissues using DRP1 mouse mAb with DAB staining.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (aa100-250) (4E11B11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
0.1 ml/$386
DNM1L / DRP1 Antibody - Anti-DNM1L antibody IHC of human brain, cerebellum, Purkinje. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DNM1L / DRP1 Rabbit anti-Human Polyclonal (aa500-600) Antibody
Bovine, Human
IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
DNM1L / DRP1 Antibody - IHC of paraffin-embedded ovarian cancer tissues using DNM1L mouse monoclonal antibody with DAB staining.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (aa69-213) (4E11B11) Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µl/$459
DNM1L / DRP1 Antibody - Immunohistochemistry of paraffin-embedded human liver injury tissue.
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DNM1L / DRP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
DNM1L / DRP1 Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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DNM1L / DRP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI4B5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-DNM1L mouse monoclonal antibody.
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4B5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (OTI4A4) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
DNM1L / DRP1 Antibody - IHC of paraffin-embedded Human pancreas tissue using anti-DNM1L mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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DNM1L / DRP1 Mouse anti-Human Monoclonal (Carrier-free) (OTI4A4) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
DNM1L / DRP1 Antibody - Immunofluorescence analysis of C6 cells using DRP1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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DNM1L / DRP1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
DNM1L / DRP1 Antibody - Western blot of Phospho-DRP1 (S637) antibody
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DNM1L / DRP1 Rabbit anti-Human Polyclonal (580-660 aa) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).