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DNASE2 / DNase II

deoxyribonuclease II, lysosomal

Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.

Gene Name:	deoxyribonuclease II, lysosomal
Family/Subfamily:	DNase
Synonyms:	DNASE2, Acid DNase, DNase II, DNase II alpha, DNASE2A, Deoxyribonuclease II alpha, Deoxyribonuclease-2-alpha, DNase II, lysosomal, R31240_2, DNL, DNL2, Lysosomal DNase II
Target Sequences:	NM_001375 NP_001366.1 O00115

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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