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DNAJA1 / HDJ2

DnaJ (Hsp40) homolog, subfamily A, member 1

Co-chaperone for HSPA8/Hsc70 (PubMed:10816573). Stimulates ATP hydrolysis, but not the folding of unfolded proteins mediated by HSPA1A (in vitro) (PubMed:24318877). Plays a role in protein transport into mitochondria via its role as co-chaperone. Functions as co-chaperone for HSPA1B and negatively regulates the translocation of BAX from the cytosol to mitochondria in response to cellular stress, thereby protecting cells against apoptosis (PubMed:14752510). Promotes apoptosis in response to cellular stress mediated by exposure to anisomycin or UV (PubMed:24512202).

Gene Name: DnaJ (Hsp40) homolog, subfamily A, member 1
Synonyms: DNAJA1, DNAJ2, HDJ-2, HDJ2, HSJ2, HSPF4, Human DnaJ protein 2, NEDD7, HSDJ, DJ-2, DjA1, DnaJ protein homolog 2, Heat shock 40 kDa protein 4, Heat shock protein J2, HSJ-2
Target Sequences: NM_001539 NP_001530.1 P31689

Publications (1)

1
The HSP40 chaperone Ydj1 drives amyloid beta 42 toxicity. Julia Ring , Jelena Tadic , Selena Ristic, Michael Poglitsch, Martina Bergmann, Nemanja Radic, Dirk Mossmann, YongTian Liang, Marta Maglione, Andrea Jerkovic, Roozbeh Hajiraissi, Marcel Hanke, Victoria Küttner, Heimo Wolinski, Andreas Zimmermann, Lana Domuz Trifunovic, Leonie Mikolasch, Daiana N Moretti, Filomena Broeskamp, Julia Westermayer, Claudia Abraham, Simon Schauer, Christopher Dammbrueck, Sebastian J Hofer, Mahmoud Abdellatif, Guido Grundmeier, Guido Kroemer, Ralf J Braun, Niklas Hansen. EMBO molecular medicine. 2022 May;14:e13952. [Full Text Article] [PubMed:35373908] [PMC:PMC9081910]

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).