DMTF1

cyclin D binding myb-like transcription factor 1

DMTF1 is a transcription factor that contains a cyclin D-binding domain, three central Myb-like repeats, and two flanking acidic transactivation domains at the N- and C-termini. The encoded protein is induced by the oncogenic Ras signaling pathway and functions as a tumor suppressor by activating the transcription of ARF and thus the ARF-p53 pathway to arrest cell growth or induce apoptosis. It also activates the transcription of aminopeptidase N and may play a role in hematopoietic cell differentiation. The transcriptional activity of this protein is regulated by binding of D-cyclins. This gene is hemizygously deleted in approximately 40% of human non-small-cell lung cancer and is a potential prognostic and gene-therapy target for non-small-cell lung cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

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Proteins (3)

Type

Over-Expression Lysate (2)

Recombinant (1)

Target

DMTF1 (3)

Publications

No (3)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

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Human DMTF1 Protein (Recombinant GST, N-terminus) (aa661-760) - LS-G61311

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human DMTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G85954

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.3 kDa

Price:

20 µg/$150

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DMTF1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110752

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

84.3 kDa

Price:

100 µg/$494

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