DMRT1

doublesex and mab-3 related transcription factor 1

Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis, leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes, such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis.

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Proteins (4)

Type

Over-Expression Lysate (2)

Recombinant (2)

Target

DMRT1 (4)

Publications

No (4)

Tag

GST (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

Purification

Purified (1)

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Human DMRT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G91563

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$150

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Human DMRT1 Protein (Recombinant GST) (Full Length) - LS-G28223

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

66.77 kDa

Price:

10 µg/$479; 25 µg/$670

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DMRT1 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G110549

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

100 µg/$494

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Human DMRT1 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72155

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

39.3 kDa

Price:

20 µg/$1,107

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