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DMD / Dystrophin

dystrophin

The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix.

Gene Name: dystrophin
Synonyms: DMD, BMD, CMD3B, DXS206, Dystrophin, DXS230, DXS239, DXS269, DXS142, DXS268, DXS164, DXS270, DXS272
Target Sequences: NM_000109 P11532 P11532

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Products
Antibodies (43)
Primary (43)
DMD / Dystrophin (43)
Human (33)
Mouse (21)
Rat (14)
Chicken (5)
Torpedo nobiliana (1)
Xenopus (1)
IHC (11)
IHC-Fr (3)
IHC-P (8)
WB (32)
ELISA (7)
EM (1)
IF (4)
IP (3)
Peptide-ELISA (1)
rabbit (36)
mouse (7)
Product Group
IHCPlus (3)
IgG (16)
IgG1 (2)
IgG1,k (1)
IgG2b (4)
monoclonal mc (7)
polyclonal pc (36)
1808 (1)
3A11 (1)
DYS-48 (3)
AP Conjugated (1)
APC (2)
APC Conjugated (3)
Azide-free (1)
Biotin Conjugated (4)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (4)
HRP Conjugated (4)
Magnetic beads Conjugated (1)
PE Conjugated (3)
Sepharose Conjugated (1)
Unconjugated (18)
aa3059-3314 (8)
aa3048-3328 (7)
C-Terminus (3)
aa3076-3404 (1)
No (43)
DMD / Dystrophin Antibody - Anti-Dystrophin antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 5 ug/ml.
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P
Unconjugated
50 µg/$440
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DMD / Dystrophin Mouse anti-Human Monoclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IF, IHC, IHC-Fr
Unconjugated
100 µl/$687
DMD / Dystrophin Antibody - Dystrophin antibody IHC-paraffin: Mouse Brain Tissue.
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DMD / Dystrophin Rabbit anti-Human Polyclonal (aa3076-3404) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$421
DMD / Dystrophin Antibody - Western Blot analysis of DMD expression in transfected 293T cell line by DMD monoclonal antibody (M07), clone 3A11.Lane 1: DMD transfected lysate(72.2 KDa).Lane 2: Non-transfected lysate.
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DMD / Dystrophin Mouse anti-Human Monoclonal (3A11) Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$413
DMD / Dystrophin Antibody - Anti-Dystrophin antibody IHC of human skeletal muscle, membrane. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Rat, Human
IHC, IHC-P
Unconjugated
250 µl/$565
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DMD / Dystrophin Mouse anti-Human Monoclonal Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-Fr, WB
Unconjugated
100 µg/$554
DMD / Dystrophin Antibody - Human skeletal muscle stained with Anti-Dystrophin antibody
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DMD / Dystrophin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
IHC, WB
Unconjugated
250 µl/$480
DMD / Dystrophin Antibody - Western blot of recombinant DMD / Dystrophin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) Antibody
Mouse
WB
Unconjugated
100 µl/$297; 200 µl/$338; 500 µl/$475; 1 ml/$543
DMD / Dystrophin Antibody - Western blot of recombinant DMD / Dystrophin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) (Biotin) Antibody
Mouse
WB
Biotin Conjugated
100 µl/$304; 200 µl/$351; 500 µl/$502; 1 ml/$580
DMD / Dystrophin Antibody - Western blot of recombinant DMD / Dystrophin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) (FITC) Antibody
Mouse
WB
FITC Conjugated
100 µl/$335; 200 µl/$392; 500 µl/$591; 1 ml/$737
DMD / Dystrophin Antibody - Western blot of recombinant DMD / Dystrophin.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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DMD / Dystrophin Rabbit anti-Mouse Polyclonal (aa3059-3314) (APC) Antibody
Mouse
WB
APC Conjugated
100 µl/$390; 200 µl/$475; 500 µl/$816; 1 ml/$889
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DMD / Dystrophin Mouse anti-Human Monoclonal (DYS-48) Antibody
Chicken, Mouse, Rat, Human
IHC, IHC-Fr, WB
Unconjugated
100 µg/$331
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DMD / Dystrophin Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
250 µl/$549
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DMD / Dystrophin Mouse anti-Human Monoclonal (Magnetic beads) (DYS-48) Antibody
Chicken, Mouse, Rat, Human
IP
Magnetic beads Conjugated
100 µg/$363
DMD / Dystrophin Antibody - Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE)
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat
IHC, IHC-P, WB
Unconjugated
50 µl/$460
DMD / Dystrophin Antibody - Western Blot; Sample: Recombinant DMD, Human.
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DMD / Dystrophin Rabbit anti-Human Polyclonal (aa3048-3328) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$319; 200 µl/$373; 500 µl/$546; 1 ml/$667
DMD / Dystrophin Antibody - Formalin-fixed, paraffin-embedded human skeletal muscle stained with peroxidase-conjugate and DAB chromogen. Note cell membrane staining of muscle fibers.  This image was taken for the unmodified form of this product. Other forms have not been tested.
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DMD / Dystrophin Mouse anti-Torpedo nobiliana Monoclonal (Azide-free) (1808) Antibody
Xenopus, Chicken, Torpedo nobiliana, Mouse, Rat, Human
EM, IF, IHC, IHC-P
Unconjugated, Azide-free
0.1 ml/$538; 0.2 ml/$853
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$321
DMD / Dystrophin Antibody - Western blot analysis of Dystrophin using NIH-3T3 whole cells lysates
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$369; 200 µl/$411
DMD / Dystrophin Antibody - Immunohistochemistry Dilution at 1:200 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal Goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated Secondary antibody and visualized using an HRP conjugated SP system.
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IHC-P
Unconjugated
50 µg/$284; 100 µg/$348
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DMD / Dystrophin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$284; 100 µg/$348
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DMD / Dystrophin Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
60 µl/$278; 120 µl/$338; 200 µl/$440
Select
DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$636
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DMD / Dystrophin Rabbit anti-Human Polyclonal (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$810
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DMD / Dystrophin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC-P
Unconjugated
100 µg/$347
Viewing 1-25 of 43 product results


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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).