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DLX5
distal-less homeobox 5
Transcriptional factor involved in bone development. Acts as an immediate early BMP-responsive transcriptional activator essential for osteoblast differentiation. Stimulates ALPL promoter activity in a RUNX2-independent manner during osteoblast differentiation. Stimulates SP7 promoter activity during osteoblast differentiation. Promotes cell proliferation by up-regulating MYC promoter activity. Involved as a positive regulator of both chondrogenesis and chondrocyte hypertrophy in the endochondral skeleton. Binds to the homeodomain-response element of the ALPL and SP7 promoter. Binds to the MYC promoter. Requires the 5'-TAATTA-3' consensus sequence for DNA-binding.
| Gene Name: | distal-less homeobox 5 |
| Synonyms: | DLX5, Distal-less homeobox 5, Homeobox protein DLX-5, Distal-less homeo box 5, SHFM1D |
| Target Sequences: | NM_005221 NP_005212.1 P56178 |
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