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DLX3

distal-less homeobox 3

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism.

Gene Name: distal-less homeobox 3
Synonyms: DLX3, AI4, Distal-less homeobox 3, TDO, Distal-less homeo box 3, Homeobox protein DLX-3
Target Sequences: NM_005220 NP_005211.1 O60479

Publications (1)

1
Gene Expression Profiles of Multiple Synchronous Lesions in Lung Adenocarcinoma. Jisun Lim, Yeon Bi Han, Soo Young Park, Soyeon Ahn, Hyojin Kim, Hyun Jung Kwon, Choon-Taek Lee, Sukki Cho, Jin-Haeng Chung. Cells. 2021 December;10: [Full Text Article] [PubMed:34943992] [PMC:PMC8700398] Related Antibodies: LS-C176704.

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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).