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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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DLL4

delta-like 4 (Drosophila)

Involved in the Notch signaling pathway as Notch ligand. Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Essential for retinal progenitor proliferation is required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types. During spinal cord neurogenesis, inhibits V2a interneuron fate.

Gene Name: delta-like 4 (Drosophila)
Synonyms: DLL4, Delta-like 4 protein, Delta like 4, Delta-like 4 (Drosophila), Delta-like 4 homolog, Drosophila Delta homolog 4, Notch ligand DLL4, Delta 4, Delta ligand 4, Delta-like protein 4, Delta4, Hdelta2, Notch ligand delta-2
Target Sequences: NM_019074 NP_061947.1 Q9NR61

Publications (2)

1
Anthrax toxins cooperatively inhibit endocytic recycling by the Rab11/Sec15 exocyst. Guichard A, McGillivray SM, Cruz-Moreno B, van Sorge NM, Nizet V, Bier E. Nature. 2010 467:854-8. (ICC; Human) [PubMed:20944747] Related Antibodies: LS-C19035.
2
Cholera toxin disrupts barrier function by inhibiting exocyst-mediated trafficking of host proteins to intestinal cell junctions. Guichard A, Cruz-Moreno B, Cruz-Moreno BC, Aguilar B, van Sorge NM, Kuang J, Kurkciyan AA, Wang Z, Hang S, Pineton de Chambrun GP, McCole DF, Watnick P, Nizet V, Bier E. Cell host & microbe. 2013 Sep;14:294-305. [Full Text Article] [PubMed:24034615] [PMC:PMC3786442] Related Antibodies: LS-C19035.

Filtered By: None
Target
DLL4 (76)
Reactivity
Human (44)
Mouse (29)
Rat (26)
Bat (1)
Bovine (5)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (5)
Horse (1)
Monkey (9)
Pig (1)
Rabbit (1)
Application
IHC (40)
IHC-Fr (5)
IHC-P (12)
WB (53)
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ELISA (30)
Func (3)
ICC (1)
IF (1)
IP (2)
Peptide-ELISA (1)
Host
rabbit (45)
mouse (14)
goat (1)
hamster (13)
rat (3)
Isotype
Ig (3)
IgG (50)
IgG1 (4)
IgG1,k (1)
IgG2a (2)
IgG2a,k (7)
IgG2b (2)
Clonality
monoclonal mc (30)
polyclonal pc (46)
Clone
12G28 (1)
4A11F8 (2)
4A11G2 (1)
DL86-3AG (1)
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Format
AP Conjugated (3)
APC (2)
APC Conjugated (3)
Biotin Conjugated (10)
Cy3 Conjugated (2)
Cy7 Conjugated (2)
FITC Conjugated (9)
HRP Conjugated (8)
Low Endotoxin (1)
PE Conjugated (5)
RPE Conjugated (1)
Unconjugated (33)
Epitope
aa214-330 (9)
aa215-331 (8)
aa146-195 (4)
aa71-120 (4)
C-Terminus (2)
Internal (2)
aa27-525 (2)
Extracellular Domain (1)
Leu617 (1)
aa123-222 (1)
aa550-600 (1)
aa586-598 (1)
Publications
No (75)
Yes (1)
Showing 1-25 of 76 results

DLL4 Antibody (aa146-195) IHC-plus™ LS-B10026
Rabbit Polyclonal (IgG) to Human DLL4
Mouse, Dog, Rat, Human, Monkey
IHC IHC-Fr WB
Unconjugated
50µg  $485.00
IHC with DLL4 antibody on frozen human tonsil.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
IHC with DLL4 antibody on frozen human tonsil.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Fetal muscle lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.  This image was taken for the unconjugated form of this product. Other forms have not been tested.

DLL4 Antibody (Internal) LS-C19035
Publications (2)
Publications (2)
Rabbit Polyclonal to Human DLL4
Human
ELISA ICC IF IHC IHC-P WB
Unconjugated
100µg 0.93mg/ml  $425.00
Anti-Delta-4 Antibody - Immunohistochemistry. Affinity Purified anti-Delta-4 antibody was used at 20 ug/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. In contrast to reported findings, no staining was observed in vascular tissue. This image shows Delta-4 staining of human ovary. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA.
Western Blot - Anti-Delta-4 Antibody. Western blot of Affinity Purified anti-Delta-4 antibody shows detection of a 74-kD band corresponding to Delta-4 in a lysate prepared from mouse pancreatic tissue. Approximately 20 ug of lysate was run on SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-Delta-4 antibody. Detection occurred using a 1:5000 dilution of HRP-labeled Goat anti-Rabbit IgG for 1 hour at room temperature. A chemiluminescence system was used for signal detection (Roche) using a 3 min exposure time.
Anti-Delta-4 Antibody - Immunohistochemistry. Affinity Purified anti-Delta-4 antibody was used at 20 ug/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. In contrast to reported findings, no staining was observed in vascular tissue. This image shows Delta-4 staining of human ovary. Tissue was formalin-fixed and paraffin embedded. Personal Communication, Tina Roush, LifeSpanBiosciences, Seattle, WA.
Western Blot - Anti-Delta-4 Antibody. Western blot of Affinity Purified anti-Delta-4 antibody shows detection of a 74-kD band corresponding to Delta-4 in a lysate prepared from mouse pancreatic tissue. Approximately 20 ug of lysate was run on SDS-PAGE and transferred onto nitrocellulose followed by reaction with a 1:500 dilution of anti-Delta-4 antibody. Detection occurred using a 1:5000 dilution of HRP-labeled Goat anti-Rabbit IgG for 1 hour at room temperature. A chemiluminescence system was used for signal detection (Roche) using a 3 min exposure time.

DLL4 Antibody (clone 4A11F8) LS-C169100
Mouse Monoclonal [clone 4A11F8] (IgG1) to Human DLL4
Human
ELISA IHC IHC-P WB
Unconjugated
100µg 1mg/ml  $365.00
IHC of paraffin-embedded rectum cancer tissues using DLL4 mouse monoclonal antibody with DAB staining.
Western blot using DLL4 monoclonal antibody against human DLL4 recombinant protein. (Expected MW is 39.2 kDa)
IHC of paraffin-embedded rectum cancer tissues using DLL4 mouse monoclonal antibody with DAB staining.
Western blot using DLL4 monoclonal antibody against human DLL4 recombinant protein. (Expected MW is 39.2 kDa)

DLL4 Antibody (aa550-600) LS-C148713
Rabbit Polyclonal to Human DLL4
Mouse, Human
WB
Unconjugated
100µg 0.5mg/ml  $335.00
Western blot of DLL4 in HUVEC cell lysate using 1) preimmune sera at 1:5000 and 2) Polyclonal Antibody to DLL4 at 3 ug/ml, and 3) mouse embryo body lysate at 6 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.
Western blot of DLL4 in HUVEC cell lysate using 1) preimmune sera at 1:5000 and 2) Polyclonal Antibody to DLL4 at 3 ug/ml, and 3) mouse embryo body lysate at 6 ug/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

DLL4 Antibody (clone 12G28) LS-C182616
Hamster Monoclonal [clone 12G28] (IgG) to Mouse DLL4
Mouse
Flo IHC
Unconjugated
100µg 1mg/ml  $405.00

DLL4 Antibody (HRP) LS-C545591
Hamster Monoclonal (IgG) to Mouse DLL4
Mouse
Flo IHC
HRP Conjugated
100µl  $545.00

DLL4 Antibody (aa27-525, Biotin) LS-C125452
Rat Monoclonal (IgG2b) to Mouse DLL4
Mouse
ELISA
Biotin Conjugated
250µg  $845.00

DLL4 Antibody (clone HMD4-2) LS-C188667
Hamster Monoclonal [clone HMD4-2] (IgG) to Mouse DLL4
Mouse
Flo Func IHC IHC-Fr IHC-P
Unconjugated
100µg 1mg/ml  $245.00; 0.25mg  $355.00

DLL4 Antibody (Internal) LS-C121719
Rabbit Polyclonal (IgG) to Human DLL4
Human
ELISA IHC IHC-P WB
Unconjugated
50µg  $605.00

DLL4 Antibody LS-C745290
Rabbit Polyclonal (IgG) to Human DLL4
Human
ELISA IHC WB
Unconjugated
25µl  $235.00
Affinity Purified anti-Delta-4 antibody was used at 20 µg/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. In contrast to reported findings, no staining was observed in vascular tissue. This image shows Delta-4 staining of human ovary. Tissue was formalin-fixed and paraffin embedded.
Western Blot of rabbit anti-DELTA-4 antibody. Lane 1: Mouse Pancreas Whole Cell Lysate. Lane 2: HUVEK Whole Cell Lysate. Lane 3: Human rDLL4. Lane 4: HEK293 Whole Cell Lysate + Human rDLL4. Lane 5: HEK293 Whole Cell Lysate. Load: 10 µg per lane for Whole Cell Lysates or 50 ng for recombinant protein. Primary antibody: DELTA-4 antibody at 1:1,000 overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody at 1:40,000 for 30 min at RT. Block: Blocking Buffer for Fluorescent Western Blotting (MB-070) for 30 min at RT. Predicted/Observed size: 74 kDa, 74 kDa for DELTA-4. Other band(s): Not Identified.
Affinity Purified anti-Delta-4 antibody was used at 20 µg/ml to detect Delta-4 in a variety of tissues including colon, liver, skeletal muscle, ovary, pancreas, prostate, testes, thymus, tonsil and uterus. In contrast to reported findings, no staining was observed in vascular tissue. This image shows Delta-4 staining of human ovary. Tissue was formalin-fixed and paraffin embedded.
Western Blot of rabbit anti-DELTA-4 antibody. Lane 1: Mouse Pancreas Whole Cell Lysate. Lane 2: HUVEK Whole Cell Lysate. Lane 3: Human rDLL4. Lane 4: HEK293 Whole Cell Lysate + Human rDLL4. Lane 5: HEK293 Whole Cell Lysate. Load: 10 µg per lane for Whole Cell Lysates or 50 ng for recombinant protein. Primary antibody: DELTA-4 antibody at 1:1,000 overnight at 4°C. Secondary antibody: Peroxidase rabbit secondary antibody at 1:40,000 for 30 min at RT. Block: Blocking Buffer for Fluorescent Western Blotting (MB-070) for 30 min at RT. Predicted/Observed size: 74 kDa, 74 kDa for DELTA-4. Other band(s): Not Identified.

DLL4 Antibody (clone 4A11G2) LS-C169087
Mouse Monoclonal [clone 4A11G2] (IgG2b) to Human DLL4
Human
ELISA Flo WB
Unconjugated
100µg 1mg/ml  $365.00
Western blot using DLL4 monoclonal antibody against human DLL4 (AA: 313-439) recombinant protein. (Expected MW is 39.2 kDa)
Western blot using DLL4 monoclonal antibody against HEK293 (1) and DLL4 (AA: 313-439)-hIgGFc transfected HEK293 (2) cell lysate.
Western blot using DLL4 monoclonal antibody against human DLL4 (AA: 313-439) recombinant protein. (Expected MW is 39.2 kDa)
Western blot using DLL4 monoclonal antibody against HEK293 (1) and DLL4 (AA: 313-439)-hIgGFc transfected HEK293 (2) cell lysate.

DLL4 Antibody LS-C411005
Rabbit Polyclonal (IgG) to Human DLL4
Human
Flo IHC WB
Unconjugated
100µl  $295.00; 200µl  $385.00

DLL4 Antibody IHC-plus™ LS-B15430
Rabbit Polyclonal (IgG) to Human DLL4
Mouse, Human
ELISA IHC IHC-P
Unconjugated
60µl  $425.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:50.
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE), at a concentration of 10 ug/ml.
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:50.

DLL4 Antibody (clone 4A11F8) LS-C355387
Mouse Monoclonal [clone 4A11F8] (IgG1) to Human DLL4
Human
IHC WB
Unconjugated
100µg  $395.00
IHC using DLL4 Antibody (4A11F8)
WB using DLL4 Antibody (4A11F8)
IHC using DLL4 Antibody (4A11F8)
WB using DLL4 Antibody (4A11F8)

DLL4 Antibody (aa214-330) LS-C293669
Rabbit Polyclonal (IgG) to Rat DLL4
Rat
IHC IHC-P WB
Unconjugated
20µl 0.5mg/ml  $205.00; 100µl 0.5mg/ml  $265.00; 200µl 0.5mg/ml  $315.00; 1ml 0.5mg/ml  $575.00; 10ml 0.5mg/ml  $2,280.00
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE)
Human Spleen: Formalin-Fixed, Paraffin-Embedded (FFPE)

DLL4 Antibody LS-C127564
Rat Monoclonal (IgG2a) to Mouse DLL4
Mouse, Human
ELISA WB
Unconjugated
500µg  $770.00

DLL4 Antibody (Leu617) LS-C64648
Rabbit Polyclonal (IgG) to Human DLL4
Human
ELISA IP WB
Unconjugated
100µl  $530.00

DLL4 Antibody LS-C751546
Rabbit Polyclonal to Human DLL4
Human
ELISA WB
Unconjugated
50µg  $285.00; 100µg  $325.00; 1mg  $1,620.00
Anti-Human sDLL-4 Western Blot Reduced
Anti-Human sDLL-4 Western Blot Unreduced
Anti-Human sDLL-4 Western Blot Reduced
Anti-Human sDLL-4 Western Blot Unreduced

DLL4 Antibody LS-C665110
Rabbit Polyclonal (IgG) to Human DLL4
Human
ELISA IP WB
Unconjugated
100µg  $375.00

DLL4 Antibody (aa123-222) LS-C307261
Mouse Monoclonal (IgG2a,k) to Human DLL4
Human
ELISA WB
Unconjugated
100µg  $560.00

DLL4 Antibody LS-C401606
Rabbit Polyclonal (IgG) to Human DLL4
Mouse, Human
ELISA IHC
Unconjugated
20µl  $205.00; 60µl  $235.00; 120µl  $295.00; 200µl  $395.00
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:40.
Immunohistochemistry of Human thyroid cancer using DLL4 Polyclonal Antibody at dilution of 1:40.

DLL4 Antibody (clone MHD4-46, Low Endotoxin) LS-C742149
Mouse Monoclonal [clone MHD4-46] (IgG1) to Human DLL4
Human
Flo Func
Unconjugated, Low Endotoxin
0.1mg  $235.00

DLL4 Antibody (clone MHD4-46) LS-C742176
Mouse Monoclonal [clone MHD4-46] (IgG1) to Human DLL4
Human
Flo Func
Unconjugated
0.1mg  $235.00

DLL4 Antibody (HRP) LS-C545590
Hamster Monoclonal (IgG) to Mouse DLL4
Mouse
Flo IHC
HRP Conjugated
100µl  $710.00

DLL4 Antibody (PE) LS-C653670
Hamster Monoclonal (IgG) to Mouse DLL4
Mouse
Flo IHC
PE Conjugated
100µl  $710.00
Showing 1-25 of 76 results

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For RESEARCH USE ONLY. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).

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