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DLK1 / Pref-1

delta-like 1 homolog (Drosophila)

DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Gene Name: delta-like 1 homolog (Drosophila)
Synonyms: DLK1, Delta-like protein dlk, DLK-1, Delta1, FA1, Dlk, Preadipocyte factor 1, Pref-1, Protein delta homolog 1, PG2, ZOG, Fetal antigen 1, PREF1, Secredeltin
Target Sequences: NM_003836 NP_003827.3 P80370

Publications (2)

1
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism. Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W. eLife. 2016 5: (Flo) [Full Text Article] [PubMed:27367842] [PMC:PMC4963200] Related Antibodies: LS-C179444.
2
Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Elisa Stellaria Grassi, Vasiliki Pantazopoulou, Alexander Pietras. Oncogene. 2020 May;39:4028-4044. [Full Text Article] [PubMed:32205867] [PMC:PMC7220882] Related Antibodies: LS-C179442.

☰ Filters
Products
Proteins (15)
Over-Expression Lysate (2)
Recombinant (13)
DLK1 / Pref-1 (15)
No (15)
6His, C-terminus (2)
6His, N-terminus (1)
DDK,C-terminus (1)
GST (1)
His (2)
His, N-Terminal (1)
His-GST (1)
His-T7 (1)
Human IgG1 Fc (2)
Myc-DDK (Flag) (3)
Human (11)
Mouse (2)
Rat (1)
293T Cells (1)
E. coli (5)
HEK 293 Cells (4)
Human Cells (1)
Mammalian Cells (2)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
Low endotoxin level (4)
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.01 EU/µg protein (determined by LAL method).
~65kDa (SDS-PAGE)
10 µg/$379
DLK1 / Pref-1 Protein - Induction of Sox-9 with the treatment of DLK1 (mouse):Fc (human) (rec.) (Prod. No. AG-40A-0107Y).Method: A mouse preadipocyte cell line, 3T3L-1, was stimulated with 5 ug/ml of mouse DLK1:Fc as shown in indicated time points and each cell lysate was prepared and subjected to western blot by using an anti-Sox-9 and anti-GAPDH antibody.
Select
HEK 293 Cells
Human IgG1 Fc
Less than 0.1 EU/µg protein (determined by LAL method).
~75kDa (SDS-PAGE)
10 µg/$379
DLK1 / Pref-1 Protein - Recombinant Delta Like 1 Homolog By SDS-PAGE
Select
E. coli
His-T7
27.9 kDa
10 µg/$287; 50 µg/$482; 100 µg/$770; 200 µg/$962; 1 mg/$2,094; 500 µg/$1,623; 5 mg/$3,361; 2 mg/$2,284
DLK1 / Pref-1 Protein - Recombinant Delta Like 1 Homolog By SDS-PAGE
Select
E. coli
His-GST
48.3 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
DLK1 / Pref-1 Protein - 12.5% SDS-PAGE of human DLK1 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
65.23 kDa
10 µg/$479; 25 µg/$670
Select
E. coli
His
33.8 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
DLK1 / Pref-1 Protein
Select
Yeast
6His, N-terminus
31.8 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
DLK1 / Pref-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
41.23 kDa
20 µg/$150
DLK1 / Pref-1 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Select
Mammalian Cells
DDK,C-terminus
100 µg/$1,009; 20 µg/$431; 1 mg/$3,451
DLK1 / Pref-1 Protein - Purified recombinant protein DLK1 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
38.7 kDa
20 µg/$1,107
DLK1 / Pref-1 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
HEK 293 Cells
Myc-DDK (Flag)
41.23 kDa
100 µg/$494
Select
Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.2 kDa
10 µg/$288; 50 µg/$436
Select
Human Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
30.15kD
10 µg/$288; 50 µg/$442; 500 µg/$1,585; 1 mg/$2,157
DLK1 / Pref-1 Protein - Recombinant Delta Like 1 Homolog By SDS-PAGE
Select
E. coli
His
17.7 kDa
10 µg/$281; 50 µg/$442; 100 µg/$705; 200 µg/$882; 1 mg/$1,989; 500 µg/$1,529; 5 mg/$3,081; 2 mg/$2,176
Select
E. coli
His, N-Terminal
19.4kDa
10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).