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DLK1 / Pref-1

delta-like 1 homolog (Drosophila)

DLK1 / Pref-1 is a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.

Gene Name: delta-like 1 homolog (Drosophila)
Synonyms: DLK1, Delta-like protein dlk, DLK-1, Delta1, FA1, Dlk, Preadipocyte factor 1, Pref-1, Protein delta homolog 1, PG2, ZOG, Fetal antigen 1, PREF1, Secredeltin
Target Sequences: NM_003836 NP_003827.3 P80370

Publications (2)

1
Glucocorticoid receptor-PPARα axis in fetal mouse liver prepares neonates for milk lipid catabolism. Rando G, Tan CK, Khaled N, Montagner A, Leuenberger N, Bertrand-Michel J, Paramalingam E, Guillou H, Wahli W. eLife. 2016 5: (Flo) [Full Text Article] [PubMed:27367842] [PMC:PMC4963200] Related Antibodies: LS-C179444.
2
Hypoxia-induced release, nuclear translocation, and signaling activity of a DLK1 intracellular fragment in glioma. Elisa Stellaria Grassi, Vasiliki Pantazopoulou, Alexander Pietras. Oncogene. 2020 May;39:4028-4044. [Full Text Article] [PubMed:32205867] [PMC:PMC7220882] Related Antibodies: LS-C179442.

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Products
ELISA Kits (15)
Custom (2)
Sandwich (12)
Sandwich CLIA (1)
DLK1 / Pref-1 (15)
Human (6)
Mouse (3)
Rat (1)
Chicken (1)
Monkey (1)
Porcine (1)
Rabbit (1)
Sheep (1)
12 x 8-Well Microstrips (1)
96-Well Microplate (2)
96-Well Strip Plate (12)
No (15)
Cell Culture Supernatants (1)
Cell Lysates (1)
Plasma (8)
Serum (8)
Tissue Homogenates (4)
Urine (1)
DLK1 / Pref-1 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.41 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Plasma, Serum
1 Plate/$700
DLK1 / Pref-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
1.56 - 100 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Urine
1 Plate/$923
DLK1 / Pref-1 ELISA Kit
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Sandwich
96-Well Strip Plate
Human
0.625 - 40 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Plasma, Serum, Tissue Homogenates
1 Plate/$902
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Sheep
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$760
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rabbit
62.5 - 4000 pg/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Chicken
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Porcine
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Monkey
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
1 Plate/$728
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
DLK1 / Pref-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Human
Colorimetric - 450nm (TMB)
1 Plate/$685
DLK1 / Pref-1 ELISA Kit
Select
Custom
96-Well Strip Plate
Mouse
Colorimetric - 450nm (TMB)
1 Plate/$783
DLK1 / Pref-1 ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
15.6 - 1000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$958
DLK1 / Pref-1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Rat
0.781 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$965
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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).