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DLG4 / PSD95
discs, large homolog 4 (Drosophila)
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.
| Gene Name: | discs, large homolog 4 (Drosophila) |
| Family/Subfamily: | MAGUK |
| Synonyms: | DLG4, Disks large homolog 4, Presynaptic density protein 95, PSD95, SAP-90, Synapse-associated protein 90, PSD-95, SAP90, Tax interaction protein 15, Discs large homolog 4 |
| Target Sequences: | NM_001365 NP_001356.1 P78352 |
Publications (4)
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