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DKK3
Dickkopf WNT Signaling Pathway Inhibitor 3
Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
| Gene Name: | Dickkopf WNT Signaling Pathway Inhibitor 3 |
| Synonyms: | DKK3, Dickkopf-3, Dkk-3, Dickkopf homolog 3, Dickkopf-related protein 3, HDkk-3, Regulated in glioma, RIG-like 7-1, REIC, RIG-like 5-6 |
| Target Sequences: | NM_013253 NP_037385.2 Q9UBP4 |
Publications (1)
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