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DISC1
Disrupted in Schizophrenia 1
Involved in the regulation of multiple aspects of embryonic and adult neurogenesis. Required for neural progenitor proliferation in the ventrical/subventrical zone during embryonic brain development and in the adult dentate gyrus of the hippocampus. Participates in the Wnt-mediated neural progenitor proliferation as a positive regulator by modulating GSK3B activity and CTNNB1 abundance. Plays a role as a modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including neuron positioning, dendritic development and synapse formation. Inhibits the activation of AKT-mTOR signaling upon interaction with CCDC88A. Regulates the migration of early-born granule cell precursors toward the dentate gyrus during the hippocampal development. Plays a role, together with PCNT, in the microtubule network formation.
| Gene Name: | Disrupted in Schizophrenia 1 |
| Synonyms: | DISC1, C1orf136, Disrupted in schizophrenia 1, KIAA0457, SCZD9 |
| Target Sequences: | NM_018662 NP_061132.2 Q9NRI5 |
Publications (2)
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