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3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mitosis, and negatively regulates cell proliferation.
Gene Name: | DIS3 mitotic control homolog (S. cerevisiae)-like 2 |
Synonyms: | DIS3L2, DIS3-like exonuclease 2, PRLMNS, FAM6A |
Target Sequences: | NM_152383 NP_689596.4 Q8IYB7 |
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