DIS3

DIS3 mitotic control homolog (S. cerevisiae)

Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities.

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Products

Antibodies (34)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (34)

Recombinant (2)

Target

DIS3 (38)

Reactivity

Human (34)

Mouse (16)

Rat (9)

Bovine (6)

Chimpanzee (3)

Dog (3)

Gibbon (6)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (6)

Zebrafish (3)

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Application

IHC (10)

IHC-P (3)

WB (30)

ELISA (15)

IF (2)

IP (3)

Peptide-ELISA (1)

Host

rabbit (27)

mouse (7)

Product Group

IHCPlus (2)

Isotype

IgG (23)

IgG2a,k (6)

Clonality

monoclonal mc (6)

polyclonal pc (28)

Format

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (5)

FITC Conjugated (5)

HRP Conjugated (5)

PE Conjugated (2)

Unconjugated (15)

Epitope

aa295-323 (7)

aa290-339 (4)

aa92-141 (4)

aa1-50 (1)

aa858-908 (1)

aa861-957 (1)

aa908-958 (1)

Publications

No (37)

Yes (1)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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IHC-plus™ DIS3 Antibody (aa295-323) LS-B9159

(4.0) Rating

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

200 µl/$460

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DIS3 Antibody (aa92-141) LS-C187155

(4.0) Rating

(1) Publication(s)

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa92-141) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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IHC-plus™ DIS3 Antibody LS-B10106

(4.0) Rating

Antibody:

DIS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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Human DIS3 Protein (Recombinant GST, N-terminus) (aa861-956) - LS-G61864

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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DIS3 Antibody LS-C665094

Antibody:

DIS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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DIS3 Antibody (aa295-323) LS-C320847

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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DIS3 Antibody (aa295-323, Biotin) LS-C208803

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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DIS3 Antibody (aa295-323, FITC) LS-C208804

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

DIS3 Antibody (aa295-323, APC) LS-C208802

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

DIS3 Antibody (aa295-323, PE) LS-C208806

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

DIS3 Antibody (aa295-323, Azide-free, HRP) LS-C208805

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa295-323) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

DIS3 Antibody LS-C802876

Antibody:

DIS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

DIS3 Antibody (aa861-957) LS-C307890

Antibody:

DIS3 Mouse anti-Human Monoclonal (aa861-957) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$705

Select

DIS3 Antibody (HRP) LS-C541808

Antibody:

DIS3 Mouse anti-Human Monoclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated

Price:

100 µl/$904

Select

DIS3 Antibody (Biotin) LS-C521675

Antibody:

DIS3 Mouse anti-Human Monoclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

100 µl/$904

Select

DIS3 Antibody (FITC) LS-C531721

Antibody:

DIS3 Mouse anti-Human Monoclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

100 µl/$904

Select

DIS3 Antibody (APC) LS-C513461

Antibody:

DIS3 Mouse anti-Human Monoclonal (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

100 µl/$904

Select

DIS3 Antibody (PE) LS-C649922

Antibody:

DIS3 Mouse anti-Human Monoclonal (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

100 µl/$904

• Unconjugated
• HRP
• Biotin
• FITC
• APC
• PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • APC
  • PE

Select

DIS3 Antibody LS-C307873

Antibody:

DIS3 Mouse anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, WB

Format:

Unconjugated

Price:

50 µg/$705

Select

DIS3 Antibody LS-C782263

Antibody:

DIS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$575

Select

DIS3 Antibody (aa1-50) LS-C290419

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa1-50) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DIS3 Antibody (aa858-908) LS-C290420

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa858-908) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DIS3 Antibody (aa908-958) LS-C290423

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa908-958) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

DIS3 Antibody (aa290-339) LS-C80373

Antibody:

DIS3 Rabbit anti-Human Polyclonal (aa290-339) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

DIS3 Antibody LS-C409569

Antibody:

DIS3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

Viewing 1-25 of 38 product results

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