DIO2

deiodinase, iodothyronine, type II

Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3&#039,5-triiodothyronine (T3). Thyroid hormone appears to have important regulatory effects in some mammalian tissues, such as the developing brain, the anterior pituitary gland, and brown adipose tissue. A relatively high proportion of the receptor-bound triiodothyronine is found within the tissue itself rather than in plasma. The expression in these tissues of type II iodothyronine deiodinase, suggests that deiodinase II is responsible for this &#039local&#039 production of T3 and is thus important in influencing thyroid hormone action in these tissues. In addition, DIO2 activity is markedly elevated in the hypothyroid state and appears to be responsible for catalyzing the production of a large proportion of the circulating T3 under such conditions. Dioiodinase 2 may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency. Alternative splice variants are formed due to the presence or absence of an unspliced intron in the 5&#039 untranslated region.

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Proteins (4)

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Recombinant (4)

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DIO2 (4)

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No (4)

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GST, N-terminus (1)

His (1)

His, N-Terminal (1)

His-MBP (1)

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Human (1)

Mouse (1)

Rat (2)

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E. coli (2)

Wheat Germ Extract (1)

Yeast (1)

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Human DIO2 Protein (Recombinant GST, N-terminus) (aa166-265) - LS-G58334

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Rat DIO2 Protein (Recombinant His-MBP) (aa30-259) - LS-G15082

Source:

E. coli

Tag:

His-MBP

Molecular Weight:

72.4 kDa

Price:

10 µg/$291; 50 µg/$502; 100 µg/$802; 200 µg/$1,002; 1 mg/$2,144; 500 µg/$1,668; 5 mg/$3,501; 2 mg/$2,334

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Rat DIO2 Protein (Recombinant His) (Full Length) - LS-G23201

Source:

Yeast

Tag:

His

Molecular Weight:

61.5 kD

Price:

100 µg/$499; 20 µg/$364; 1 mg/$1,683

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Mouse DIO2 Protein (Recombinant His, N-Terminal) (Ser30-Phe259) - LS-G133037

Source:

E. coli

Tag:

His, N-Terminal

Molecular Weight:

72.4kDa

Price:

10 µg/$267; 50 µg/$352; 200 µg/$702; 100 µg/$562; 1 mg/$1,723; 500 µg/$1,298; 5 mg/$2,673; 2 mg/$1,900

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