DIO2

deiodinase, iodothyronine, type II

Type II iodothyronine deiodinase activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3&#039,5-triiodothyronine (T3). Thyroid hormone appears to have important regulatory effects in some mammalian tissues, such as the developing brain, the anterior pituitary gland, and brown adipose tissue. A relatively high proportion of the receptor-bound triiodothyronine is found within the tissue itself rather than in plasma. The expression in these tissues of type II iodothyronine deiodinase, suggests that deiodinase II is responsible for this &#039local&#039 production of T3 and is thus important in influencing thyroid hormone action in these tissues. In addition, DIO2 activity is markedly elevated in the hypothyroid state and appears to be responsible for catalyzing the production of a large proportion of the circulating T3 under such conditions. Dioiodinase 2 may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease, toxic adenomas, and, perhaps, iodine deficiency. Alternative splice variants are formed due to the presence or absence of an unspliced intron in the 5&#039 untranslated region.

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Products

Antibodies (26)

Type

Primary (26)

Target

DIO2 (26)

Reactivity

Human (23)

Mouse (16)

Rat (11)

Pig (1)

Application

IHC (4)

IHC-P (2)

WB (20)

Flo (1)

ELISA (9)

ICC (2)

IF (2)

Peptide-ELISA (2)

Host

rabbit (25)

goat (1)

Isotype

IgG (12)

Clonality

polyclonal pc (26)

Format

APC (1)

APC Conjugated (2)

Azide-free (1)

Biotin Conjugated (4)

Cy3 Conjugated (1)

Cy7 Conjugated (1)

FITC Conjugated (4)

HRP Conjugated (3)

PE Conjugated (2)

Unconjugated (9)

Epitope

aa30-259 (11)

aa165-191 (7)

aa217-228 (1)

Publications

No (26)

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DIO2 Antibody LS-C671307

Antibody:

DIO2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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DIO2 Antibody (HRP) LS-C671305

Antibody:

DIO2 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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DIO2 Antibody (Biotin) LS-C671309

Antibody:

DIO2 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

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DIO2 Antibody (FITC) LS-C671308

Antibody:

DIO2 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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DIO2 Antibody (aa217-228) LS-C61730

Antibody:

DIO2 Goat anti-Human Polyclonal (aa217-228) Antibody

Reactivity:

Mouse, Pig, Human

Applications:

IF, IHC, Peptide-ELISA

Format:

Unconjugated

Price:

100 µg/$503

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DIO2 Antibody LS-C403113

Antibody:

DIO2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450

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DIO2 Antibody (aa30-259, FITC) LS-C422777

Antibody:

DIO2 Rabbit anti-Mouse Polyclonal (aa30-259) (FITC) Antibody

Reactivity:

Mouse

Applications:

ICC, WB

Format:

FITC Conjugated

Price:

100 µl/$331

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DIO2 Antibody (aa30-259, Biotin) LS-C422812

Antibody:

DIO2 Rabbit anti-Mouse Polyclonal (aa30-259) (Biotin) Antibody

Reactivity:

Mouse

Applications:

ICC, WB

Format:

Biotin Conjugated

Price:

100 µl/$321

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DIO2 Antibody (aa165-191) LS-C327196

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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DIO2 Antibody (aa165-191, Biotin) LS-C276769

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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DIO2 Antibody (aa165-191, FITC) LS-C276771

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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DIO2 Antibody (aa165-191, APC) LS-C276770

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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DIO2 Antibody (aa165-191, PE) LS-C276773

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

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DIO2 Antibody (aa165-191, Azide-free, HRP) LS-C276772

Antibody:

DIO2 Rabbit anti-Human Polyclonal (aa165-191) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

DIO2 Antibody LS-C780948

Antibody:

DIO2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

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DIO2 Antibody LS-C803318

Antibody:

DIO2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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DIO2 Antibody (aa30-259) LS-C314935

Antibody:

DIO2 Rabbit anti-Mouse Polyclonal (aa30-259) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$311; 200 µl/$355; 500 µl/$499; 1 ml/$571

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DIO2 Antibody (aa30-259) LS-C293664

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331

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DIO2 Antibody (aa30-259, HRP) LS-C712029

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (HRP) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$349; 200 µl/$408; 500 µl/$609; 1 ml/$762; 2 ml/$999; 5 ml/$1,729

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DIO2 Antibody (aa30-259, Biotin) LS-C687550

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (Biotin) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$328; 200 µl/$378; 500 µl/$545; 1 ml/$645; 2 ml/$879; 5 ml/$1,464

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DIO2 Antibody (aa30-259, FITC) LS-C694378

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (FITC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$359; 200 µl/$423; 500 µl/$655; 1 ml/$816; 2 ml/$1,055; 5 ml/$1,863

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DIO2 Antibody (aa30-259, Cy3) LS-C703004

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (Cy3) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Cy3 Conjugated

Price:

100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661

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DIO2 Antibody (aa30-259, APC) LS-C718095

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (APC) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

APC Conjugated

Price:

100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661

Select

DIO2 Antibody (aa30-259, APC, Cy7) LS-C735036

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (APC, Cy7) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

APC, Cy7 Conjugated

Price:

100 µl/$530; 200 µl/$703; 500 µl/$1,217; 1 ml/$1,521; 2 ml/$2,129; 5 ml/$3,991

Select

DIO2 Antibody (aa30-259, PE) LS-C726090

Antibody:

DIO2 Rabbit anti-Rat Polyclonal (aa30-259) (PE) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

PE Conjugated

Price:

100 µl/$423; 200 µl/$515; 500 µl/$906; 1 ml/$1,071; 2 ml/$1,420; 5 ml/$2,661

• Unconjugated
• HRP
• Biotin
• FITC
• Cy3
• APC
• APC, Cy7
• More...
  • PE

• Unconjugated
• HRP
• Biotin
• More...
  • FITC
  • Cy3
  • APC
  • APC, Cy7
  • PE

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